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MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations
MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate gene expression on post-transcriptional level via inhibition or degradation of specific mRNAs. MiRNAs in cells are the primary regulators of functions such as cell growth, differentiation, and apoptosis and cons...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460809/ https://www.ncbi.nlm.nih.gov/pubmed/37646065 http://dx.doi.org/10.34172/apb.2023.047 |
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author | Shademan, Behrouz Karamad, Vahidreza Nourazarian, Alireza Masjedi, Sepideh Isazadeh, Alireza Sogutlu, Fatma Avcı, Cigir Biray |
author_facet | Shademan, Behrouz Karamad, Vahidreza Nourazarian, Alireza Masjedi, Sepideh Isazadeh, Alireza Sogutlu, Fatma Avcı, Cigir Biray |
author_sort | Shademan, Behrouz |
collection | PubMed |
description | MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate gene expression on post-transcriptional level via inhibition or degradation of specific mRNAs. MiRNAs in cells are the primary regulators of functions such as cell growth, differentiation, and apoptosis and considerably influence cell function. The expression levels of microRNAs change in human diseases, including cancer. These changes highlight their essential role in cancer pathogenesis. Ubiquitous irregular expression profiles of miRNAs have been detected in various human cancers using genome-wide identification techniques, which are emerging as novel diagnostic and prognostic cancer biomarkers of high specificity and sensitivity. The measurable miRNAs with enhanced stability in blood, tissues, and other body fluids provide a comprehensive source of miRNA-dependent biomarkers for human cancers. The leading role of miRNAs as potential biomarkers in human cancers is discussed in this article. In addition, the interests and difficulties of miRNAs as biomarkers have been explored. |
format | Online Article Text |
id | pubmed-10460809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-104608092023-08-29 MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations Shademan, Behrouz Karamad, Vahidreza Nourazarian, Alireza Masjedi, Sepideh Isazadeh, Alireza Sogutlu, Fatma Avcı, Cigir Biray Adv Pharm Bull Review Article MicroRNAs are small RNAs with ability to attach to the large number of RNA that regulate gene expression on post-transcriptional level via inhibition or degradation of specific mRNAs. MiRNAs in cells are the primary regulators of functions such as cell growth, differentiation, and apoptosis and considerably influence cell function. The expression levels of microRNAs change in human diseases, including cancer. These changes highlight their essential role in cancer pathogenesis. Ubiquitous irregular expression profiles of miRNAs have been detected in various human cancers using genome-wide identification techniques, which are emerging as novel diagnostic and prognostic cancer biomarkers of high specificity and sensitivity. The measurable miRNAs with enhanced stability in blood, tissues, and other body fluids provide a comprehensive source of miRNA-dependent biomarkers for human cancers. The leading role of miRNAs as potential biomarkers in human cancers is discussed in this article. In addition, the interests and difficulties of miRNAs as biomarkers have been explored. Tabriz University of Medical Sciences 2023-07 2022-07-02 /pmc/articles/PMC10460809/ /pubmed/37646065 http://dx.doi.org/10.34172/apb.2023.047 Text en ©2023 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers. |
spellingShingle | Review Article Shademan, Behrouz Karamad, Vahidreza Nourazarian, Alireza Masjedi, Sepideh Isazadeh, Alireza Sogutlu, Fatma Avcı, Cigir Biray MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title | MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title_full | MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title_fullStr | MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title_full_unstemmed | MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title_short | MicroRNAs as Targets for Cancer Diagnosis: Interests and Limitations |
title_sort | micrornas as targets for cancer diagnosis: interests and limitations |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460809/ https://www.ncbi.nlm.nih.gov/pubmed/37646065 http://dx.doi.org/10.34172/apb.2023.047 |
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