Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk (Adv. Sci. 24/2023)

3D Fibrillar Fibronectin In article number 2300812, Seungkuk Ahn, Nico Strohmeyer, Daniel J. Muller, and co‐workers report a simple and easily‐adaptable method to engineer 3D fibrillar fibronectin matrices mimicking native fibrillar tissues. Fibroblasts sense and respond to the biomimetic 3D fibrill...

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Detalles Bibliográficos
Autores principales: Ahn, Seungkuk, Sharma, Upnishad, Kasuba, Krishna Chaitanya, Strohmeyer, Nico, Müller, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10460894/
http://dx.doi.org/10.1002/advs.202370163
Descripción
Sumario:3D Fibrillar Fibronectin In article number 2300812, Seungkuk Ahn, Nico Strohmeyer, Daniel J. Muller, and co‐workers report a simple and easily‐adaptable method to engineer 3D fibrillar fibronectin matrices mimicking native fibrillar tissues. Fibroblasts sense and respond to the biomimetic 3D fibrillar matrices via α5β1 integrin and syndecan‐4, which crosstalk to accelerate adhesion within seconds. This rapid fibrillar sensing guides cell growth, migration, and proliferation as depicted in the frontispiece. [Image: see text]

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