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Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function

Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well known after decades of studies. Yet our current understanding of the intrinsic determinants regulating PrP misfolding...

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Detalles Bibliográficos
Autores principales:	Cembran, Alessandro, Fernandez-Funez, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461008/ https://www.ncbi.nlm.nih.gov/pubmed/37645703 http://dx.doi.org/10.3389/fnmol.2023.1231079

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