Cargando…

Intrinsic determinants of prion protein neurotoxicity in Drosophila: from sequence to (dys)function

Prion diseases are fatal brain disorders characterized by deposition of insoluble isoforms of the prion protein (PrP). The normal and pathogenic structures of PrP are relatively well known after decades of studies. Yet our current understanding of the intrinsic determinants regulating PrP misfolding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cembran, Alessandro, Fernandez-Funez, Pedro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461008/ https://www.ncbi.nlm.nih.gov/pubmed/37645703 http://dx.doi.org/10.3389/fnmol.2023.1231079

Ejemplares similares

Insight From Animals Resistant to Prion Diseases: Deciphering the Genotype – Morphotype – Phenotype Code for the Prion Protein
por: Myers, Ryan, et al.
Publicado: (2020)

Y225A induces long-range conformational changes in human prion protein that are protective in Drosophila
por: Myers, Ryan R., et al.
Publicado: (2023)

Combined Pharmacological Induction of Hsp70 Suppresses Prion Protein Neurotoxicity in Drosophila
por: Zhang, Yan, et al.
Publicado: (2014)

New Drosophila models to uncover the intrinsic and extrinsic factors that mediate the toxicity of the human prion protein
por: Myers, Ryan R., et al.
Publicado: (2022)

Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease
por: Thackray, Alana M., et al.
Publicado: (2020)

In Vivo Generation of Neurotoxic Prion Protein: Role for Hsp70 in Accumulation of Misfolded Isoforms
por: Fernandez-Funez, Pedro, et al.
Publicado: (2009)

Conservation of Prion-Like Composition and Sequence in Prion-Formers and Prion-Like Proteins of Saccharomyces cerevisiae
por: Su, Ting-Yi, et al.
Publicado: (2019)

Role of Prion Protein Aggregation in Neurotoxicity
por: Corsaro, Alessandro, et al.
Publicado: (2012)

Translocator Protein Ligand Etifoxine Attenuates MPTP-Induced Neurotoxicity
por: Tian, Qi, et al.
Publicado: (2022)

An N-terminal Fragment of the Prion Protein Binds to Amyloid-β Oligomers and Inhibits Their Neurotoxicity in Vivo
por: Fluharty, Brian R., et al.
Publicado: (2013)

Physiological Functions of the Cellular Prion Protein
por: Castle, Andrew R., et al.
Publicado: (2017)

How structure shapes (dys)function: A perspective to understanding brain region-specific degeneration in prion disease
por: Šišková, Zuzana
Publicado: (2013)

What is the role of lipids in prion conversion and disease?
por: Alves Conceição, Cyntia, et al.
Publicado: (2023)

Editorial: Glia-Mediated Neurotoxicity: Uncovering the Molecular Mechanisms
por: Srivastava, Amit K., et al.
Publicado: (2022)

Neurotoxicity of Prion Peptides Mimicking the Central Domain of the Cellular Prion Protein
por: Vilches, Silvia, et al.
Publicado: (2013)

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication
por: Frontzek, Karl, et al.
Publicado: (2016)

S-Glutathionylation in Monocyte and Macrophage (Dys)Function
por: Ullevig, Sarah, et al.
Publicado: (2013)

Sexual (Dys)function after Urethroplasty
por: Xambre, Luís
Publicado: (2016)

Cardiolipin externalization mediates prion protein (PrP) peptide 106–126-associated mitophagy and mitochondrial dysfunction
por: Yang, Dongming, et al.
Publicado: (2023)

In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers
por: Simoneau, Steve, et al.
Publicado: (2007)

Vitamin K(2) protects against Aβ42-induced neurotoxicity by activating autophagy and improving mitochondrial function in Drosophila
por: Lin, Xiaohui, et al.
Publicado: (2021)

Prion Protein Misfolding, Strains, and Neurotoxicity: An Update from Studies on Mammalian Prions
por: Poggiolini, Ilaria, et al.
Publicado: (2013)

Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile
por: Marrone, April K, et al.
Publicado: (2012)

Editorial: Probabilistic Perspectives on Brain (Dys)function
por: Parr, Thomas, et al.
Publicado: (2021)

Editorial: Prion and prion-like proteins in neurodegenerative diseases
por: Toni, Mattia, et al.
Publicado: (2022)

Unexpected decrease of full-length prion protein in macaques inoculated with prion-contaminated blood products
por: Jaffré, Nina, et al.
Publicado: (2023)

Neurotoxic effects of different sizes of plastics (nano, micro, and macro) on juvenile common carp (Cyprinus carpio)
por: Hamed, Mohamed, et al.
Publicado: (2022)

Endoproteolysis of cellular prion protein by plasmin hinders propagation of prions
por: Mays, Charles E., et al.
Publicado: (2022)

Endothelial Nanomechanics in the Context of Endothelial (Dys)function and Inflammation
por: Fels, Johannes, et al.
Publicado: (2019)

The contribution of DNA methylation to the (dys)function of oligodendroglia in neurodegeneration
por: Fodder, Katherine, et al.
Publicado: (2023)

Prions: Generation and Spread Versus Neurotoxicity
por: Halliday, Mark, et al.
Publicado: (2014)

Highly infectious prions are not directly neurotoxic
por: Benilova, Iryna, et al.
Publicado: (2020)

The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila
por: Sharma, Yashoda, et al.
Publicado: (2023)

Thyroid (Dys)Function in Heart Failure: Is it a Potential Target for Medical Treatment?
por: Pingitore, Alessandro, et al.
Publicado: (2005)

The identification of protein and RNA interactors of the splicing factor Caper in the adult Drosophila nervous system
por: Titus, M. Brandon, et al.
Publicado: (2023)

N-glycosylation is a potent regulator of prion protein neurotoxicity
por: Schilling, Kevin M., et al.
Publicado: (2023)

Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer’s disease
por: Alalwany, Roaa H., et al.
Publicado: (2023)

(Dys)regulation of Synaptic Activity and Neurotransmitter Release by β-Amyloid: A Look Beyond Alzheimer's Disease Pathogenesis
por: Fagiani, Francesca, et al.
Publicado: (2021)

Overexpression of quality control proteins reduces prion conversion in prion-infected cells
por: Thapa, Simrika, et al.
Publicado: (2018)

Computational approaches for inferring the functions of intrinsically disordered proteins
por: Varadi, Mihaly, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vj3led1kah2moi2dorkga9vecf