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Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, the cumulative number of infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite the marketing of multiple series of vaccines and the imp...

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Autores principales: Zeng, Zhaomu, Geng, Xiuchao, Wen, Xichao, Chen, Yueyue, Zhu, Yixi, Dong, Zishu, Hao, Liangchao, Wang, Tingting, Yang, Jifeng, Zhang, Ruobing, Zheng, Kebin, Sun, Zhiwei, Zhang, Yuhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461067/
https://www.ncbi.nlm.nih.gov/pubmed/37645223
http://dx.doi.org/10.3389/fmicb.2023.1232453
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author Zeng, Zhaomu
Geng, Xiuchao
Wen, Xichao
Chen, Yueyue
Zhu, Yixi
Dong, Zishu
Hao, Liangchao
Wang, Tingting
Yang, Jifeng
Zhang, Ruobing
Zheng, Kebin
Sun, Zhiwei
Zhang, Yuhao
author_facet Zeng, Zhaomu
Geng, Xiuchao
Wen, Xichao
Chen, Yueyue
Zhu, Yixi
Dong, Zishu
Hao, Liangchao
Wang, Tingting
Yang, Jifeng
Zhang, Ruobing
Zheng, Kebin
Sun, Zhiwei
Zhang, Yuhao
author_sort Zeng, Zhaomu
collection PubMed
description Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, the cumulative number of infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite the marketing of multiple series of vaccines and the implementation of strict prevention and control measures in many countries, the spread and prevalence of SARS-CoV-2 have not been completely and effectively controlled. The latest research shows that in addition to angiotensin converting enzyme II (ACE2), dozens of protein molecules, including AXL, can act as host receptors for SARS-CoV-2 infecting human cells, and virus mutation and immune evasion never seem to stop. To sum up, this review summarizes and organizes the latest relevant literature, comprehensively reviews the genome characteristics of SARS-CoV-2 as well as receptor-based pathogenesis (including ACE2 and other new receptors), mutation and immune evasion, vaccine development and other aspects, and proposes a series of prevention and treatment opinions. It is expected to provide a theoretical basis for an in-depth understanding of the pathogenic mechanism of SARS-CoV-2 along with a research basis and new ideas for the diagnosis and classification, of COVID-19-related disease and for drug and vaccine research and development.
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spelling pubmed-104610672023-08-29 Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future Zeng, Zhaomu Geng, Xiuchao Wen, Xichao Chen, Yueyue Zhu, Yixi Dong, Zishu Hao, Liangchao Wang, Tingting Yang, Jifeng Zhang, Ruobing Zheng, Kebin Sun, Zhiwei Zhang, Yuhao Front Microbiol Microbiology Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its resultant pneumonia in December 2019, the cumulative number of infected people worldwide has exceeded 670 million, with over 6.8 million deaths. Despite the marketing of multiple series of vaccines and the implementation of strict prevention and control measures in many countries, the spread and prevalence of SARS-CoV-2 have not been completely and effectively controlled. The latest research shows that in addition to angiotensin converting enzyme II (ACE2), dozens of protein molecules, including AXL, can act as host receptors for SARS-CoV-2 infecting human cells, and virus mutation and immune evasion never seem to stop. To sum up, this review summarizes and organizes the latest relevant literature, comprehensively reviews the genome characteristics of SARS-CoV-2 as well as receptor-based pathogenesis (including ACE2 and other new receptors), mutation and immune evasion, vaccine development and other aspects, and proposes a series of prevention and treatment opinions. It is expected to provide a theoretical basis for an in-depth understanding of the pathogenic mechanism of SARS-CoV-2 along with a research basis and new ideas for the diagnosis and classification, of COVID-19-related disease and for drug and vaccine research and development. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461067/ /pubmed/37645223 http://dx.doi.org/10.3389/fmicb.2023.1232453 Text en Copyright © 2023 Zeng, Geng, Wen, Chen, Zhu, Dong, Hao, Wang, Yang, Zhang, Zheng, Sun and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zeng, Zhaomu
Geng, Xiuchao
Wen, Xichao
Chen, Yueyue
Zhu, Yixi
Dong, Zishu
Hao, Liangchao
Wang, Tingting
Yang, Jifeng
Zhang, Ruobing
Zheng, Kebin
Sun, Zhiwei
Zhang, Yuhao
Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title_full Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title_fullStr Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title_full_unstemmed Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title_short Novel receptor, mutation, vaccine, and establishment of coping mode for SARS-CoV-2: current status and future
title_sort novel receptor, mutation, vaccine, and establishment of coping mode for sars-cov-2: current status and future
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461067/
https://www.ncbi.nlm.nih.gov/pubmed/37645223
http://dx.doi.org/10.3389/fmicb.2023.1232453
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