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Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evoluti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461088/ https://www.ncbi.nlm.nih.gov/pubmed/37646021 http://dx.doi.org/10.3389/fimmu.2023.1195194 |
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author | Lang, Yue Lyu, Yanan Tan, Yehui Hu, Zheng |
author_facet | Lang, Yue Lyu, Yanan Tan, Yehui Hu, Zheng |
author_sort | Lang, Yue |
collection | PubMed |
description | Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evolutionary divergence, whereas the mouse models hosting human hematological malignancy are more and more applied in basic as well as translational investigations in recent years. According to the construction methods, they can be divided into different types (e.g. cell-derived xenograft (CDX) and patient-derived xenograft model (PDX) model) that have diverse characteristics and application values. In addition, a variety of strategies have been developed to improve human hematological malignant cell engraftment and differentiation in vivo. Moreover, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for the evaluation of the efficacy of novel immunotherapeutic drugs/approaches. Herein, we first review the evolution of the mouse model of human hematological malignancy; Then, we analyze the characteristics of different types of models and summarize the ways to improve the models; Finally, the way and value of humanized mouse model of human immune system in the immunotherapy of human hematological malignancy are discussed. |
format | Online Article Text |
id | pubmed-10461088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104610882023-08-29 Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy Lang, Yue Lyu, Yanan Tan, Yehui Hu, Zheng Front Immunol Immunology Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evolutionary divergence, whereas the mouse models hosting human hematological malignancy are more and more applied in basic as well as translational investigations in recent years. According to the construction methods, they can be divided into different types (e.g. cell-derived xenograft (CDX) and patient-derived xenograft model (PDX) model) that have diverse characteristics and application values. In addition, a variety of strategies have been developed to improve human hematological malignant cell engraftment and differentiation in vivo. Moreover, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for the evaluation of the efficacy of novel immunotherapeutic drugs/approaches. Herein, we first review the evolution of the mouse model of human hematological malignancy; Then, we analyze the characteristics of different types of models and summarize the ways to improve the models; Finally, the way and value of humanized mouse model of human immune system in the immunotherapy of human hematological malignancy are discussed. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461088/ /pubmed/37646021 http://dx.doi.org/10.3389/fimmu.2023.1195194 Text en Copyright © 2023 Lang, Lyu, Tan and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lang, Yue Lyu, Yanan Tan, Yehui Hu, Zheng Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title | Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title_full | Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title_fullStr | Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title_full_unstemmed | Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title_short | Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
title_sort | progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461088/ https://www.ncbi.nlm.nih.gov/pubmed/37646021 http://dx.doi.org/10.3389/fimmu.2023.1195194 |
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