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Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy

Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evoluti...

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Autores principales: Lang, Yue, Lyu, Yanan, Tan, Yehui, Hu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461088/
https://www.ncbi.nlm.nih.gov/pubmed/37646021
http://dx.doi.org/10.3389/fimmu.2023.1195194
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author Lang, Yue
Lyu, Yanan
Tan, Yehui
Hu, Zheng
author_facet Lang, Yue
Lyu, Yanan
Tan, Yehui
Hu, Zheng
author_sort Lang, Yue
collection PubMed
description Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evolutionary divergence, whereas the mouse models hosting human hematological malignancy are more and more applied in basic as well as translational investigations in recent years. According to the construction methods, they can be divided into different types (e.g. cell-derived xenograft (CDX) and patient-derived xenograft model (PDX) model) that have diverse characteristics and application values. In addition, a variety of strategies have been developed to improve human hematological malignant cell engraftment and differentiation in vivo. Moreover, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for the evaluation of the efficacy of novel immunotherapeutic drugs/approaches. Herein, we first review the evolution of the mouse model of human hematological malignancy; Then, we analyze the characteristics of different types of models and summarize the ways to improve the models; Finally, the way and value of humanized mouse model of human immune system in the immunotherapy of human hematological malignancy are discussed.
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spelling pubmed-104610882023-08-29 Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy Lang, Yue Lyu, Yanan Tan, Yehui Hu, Zheng Front Immunol Immunology Hematological malignancy is a disease arisen by complicate reasons that seriously endangers human health. The research on its pathogenesis and therapies depends on the usage of animal models. Conventional animal model cannot faithfully mirror some characteristics of human features due to the evolutionary divergence, whereas the mouse models hosting human hematological malignancy are more and more applied in basic as well as translational investigations in recent years. According to the construction methods, they can be divided into different types (e.g. cell-derived xenograft (CDX) and patient-derived xenograft model (PDX) model) that have diverse characteristics and application values. In addition, a variety of strategies have been developed to improve human hematological malignant cell engraftment and differentiation in vivo. Moreover, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for the evaluation of the efficacy of novel immunotherapeutic drugs/approaches. Herein, we first review the evolution of the mouse model of human hematological malignancy; Then, we analyze the characteristics of different types of models and summarize the ways to improve the models; Finally, the way and value of humanized mouse model of human immune system in the immunotherapy of human hematological malignancy are discussed. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461088/ /pubmed/37646021 http://dx.doi.org/10.3389/fimmu.2023.1195194 Text en Copyright © 2023 Lang, Lyu, Tan and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lang, Yue
Lyu, Yanan
Tan, Yehui
Hu, Zheng
Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title_full Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title_fullStr Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title_full_unstemmed Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title_short Progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
title_sort progress in construction of mouse models to investigate the pathogenesis and immune therapy of human hematological malignancy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461088/
https://www.ncbi.nlm.nih.gov/pubmed/37646021
http://dx.doi.org/10.3389/fimmu.2023.1195194
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