Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears

Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively dru...

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Detalles Bibliográficos
Autores principales: Wang, Taylor, Jain, Sumeet, Glidai, Yoav, Dua, Prachi, Dempsey, Katharine S., Shakin, Eric, Chu, David S., Epstein, Marcia, Ha, Lawrence G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461124/
https://www.ncbi.nlm.nih.gov/pubmed/37645532
http://dx.doi.org/10.1016/j.idcr.2023.e01839
Descripción
Sumario:Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) P. aeruginosa panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens.

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