Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears

Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively dru...

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Autores principales: Wang, Taylor, Jain, Sumeet, Glidai, Yoav, Dua, Prachi, Dempsey, Katharine S., Shakin, Eric, Chu, David S., Epstein, Marcia, Ha, Lawrence G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461124/
https://www.ncbi.nlm.nih.gov/pubmed/37645532
http://dx.doi.org/10.1016/j.idcr.2023.e01839
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author Wang, Taylor
Jain, Sumeet
Glidai, Yoav
Dua, Prachi
Dempsey, Katharine S.
Shakin, Eric
Chu, David S.
Epstein, Marcia
Ha, Lawrence G.
author_facet Wang, Taylor
Jain, Sumeet
Glidai, Yoav
Dua, Prachi
Dempsey, Katharine S.
Shakin, Eric
Chu, David S.
Epstein, Marcia
Ha, Lawrence G.
author_sort Wang, Taylor
collection PubMed
description Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) P. aeruginosa panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens.
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spelling pubmed-104611242023-08-29 Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears Wang, Taylor Jain, Sumeet Glidai, Yoav Dua, Prachi Dempsey, Katharine S. Shakin, Eric Chu, David S. Epstein, Marcia Ha, Lawrence G. IDCases Case Report Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) P. aeruginosa panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens. Elsevier 2023-07-05 /pmc/articles/PMC10461124/ /pubmed/37645532 http://dx.doi.org/10.1016/j.idcr.2023.e01839 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wang, Taylor
Jain, Sumeet
Glidai, Yoav
Dua, Prachi
Dempsey, Katharine S.
Shakin, Eric
Chu, David S.
Epstein, Marcia
Ha, Lawrence G.
Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title_full Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title_fullStr Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title_full_unstemmed Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title_short Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
title_sort extensively drug-resistant pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461124/
https://www.ncbi.nlm.nih.gov/pubmed/37645532
http://dx.doi.org/10.1016/j.idcr.2023.e01839
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