Creation of a Peptide Antagonist of the GFRAL–RET Receptor Complex for the Treatment of GDF15-Induced Malaise

[Image: see text] Growth differentiation factor 15 (GDF15) is a contributor to nausea, emesis, and anorexia following chemotherapy via binding to the GFRAL-RET receptor complex expressed in hindbrain neurons. Therefore, GDF15-mediated GFRAL-RET signaling is a promising target for improving treatment...

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Detalles Bibliográficos
Autores principales: Borner, Tito, Tinsley, Ian C., Milliken, Brandon T., Doebley, Sarah A., Najjar, Nicholas R., Kerwood, Deborah J., De Jonghe, Bart C., Hayes, Matthew R., Doyle, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461225/
https://www.ncbi.nlm.nih.gov/pubmed/37506293
http://dx.doi.org/10.1021/acs.jmedchem.3c00667

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