Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity

[Image: see text] The design and synthesis of a series of 2,7-diazaspiro[4.4]nonane derivatives as potent sigma receptor (SR) ligands, associated with analgesic activity, are the focus of this work. In this study, affinities at S1R and S2R were measured, and molecular modeling studies were performed...

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Detalles Bibliográficos
Autores principales: Dichiara, Maria, Ambrosio, Francesca Alessandra, Lee, Sang Min, Ruiz-Cantero, M. Carmen, Lombino, Jessica, Coricello, Adriana, Costa, Giosuè, Shah, Dhara, Costanzo, Giuliana, Pasquinucci, Lorella, Son, Kyung No, Cosentino, Giuseppe, González-Cano, Rafael, Marrazzo, Agostino, Aakalu, Vinay Kumar, Cobos, Enrique J., Alcaro, Stefano, Amata, Emanuele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461227/
https://www.ncbi.nlm.nih.gov/pubmed/37535861
http://dx.doi.org/10.1021/acs.jmedchem.3c00959

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