Design, Synthesis, and Evaluation of Novel Δ(2)-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant

[Image: see text] Mycobacterium tuberculosis (Mtb) drug resistance poses an alarming threat to global tuberculosis control. We previously reported that C10, a ring-fused thiazolo-2-pyridone, inhibits Mtb respiration, blocks biofilm formation, and restores the activity of the antibiotic isoniazid (IN...

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Detalles Bibliográficos
Autores principales: Sarkar, Souvik, Mayer Bridwell, Anne E., Good, James A. D., Wang, Erin R., McKee, Samuel R., Valenta, Joy, Harrison, Gregory A., Flentie, Kelly N., Henry, Frederick L., Wixe, Torbjörn, Demirel, Peter, Vagolu, Siva K., Chatagnon, Jonathan, Machelart, Arnaud, Brodin, Priscille, Tønjum, Tone, Stallings, Christina L., Almqvist, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461229/
https://www.ncbi.nlm.nih.gov/pubmed/37485869
http://dx.doi.org/10.1021/acs.jmedchem.3c00358

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