Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

[Image: see text] Multitargeted agents provide tumor selectivity with reduced drug resistance and dose-limiting toxicities. We previously described the multitargeted 6-substituted pyrrolo[3,2-d]pyrimidine antifolate 1 with activity against early- and late-stage pancreatic tumors with limited tumor s...

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Detalles Bibliográficos
Autores principales: Nayeen, Md. Junayed, Katinas, Jade M., Magdum, Tejashree, Shah, Khushbu, Wong, Jennifer E., O’Connor, Carrie E., Fifer, Alexandra N., Wallace-Povirk, Adrianne, Hou, Zhanjun, Matherly, Larry H., Dann, Charles E., Gangjee, Aleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461232/
https://www.ncbi.nlm.nih.gov/pubmed/37582241
http://dx.doi.org/10.1021/acs.jmedchem.3c00763

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