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Corticosteroids in COVID-19: pros and cons
The wide and rapid spread of the COVID-19 pandemic has placed an unanticipated burden on the global healthcare sector. This necessitated a swift response from the international community to reach a solution. Efforts were made in parallel to develop preventative and therapeutic modalities. Since then...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461317/ https://www.ncbi.nlm.nih.gov/pubmed/37644981 http://dx.doi.org/10.3389/fmed.2023.1202504 |
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author | Bahsoun, Aymen Fakih, Yeva Zareef, Rana Bitar, Fadi Arabi, Mariam |
author_facet | Bahsoun, Aymen Fakih, Yeva Zareef, Rana Bitar, Fadi Arabi, Mariam |
author_sort | Bahsoun, Aymen |
collection | PubMed |
description | The wide and rapid spread of the COVID-19 pandemic has placed an unanticipated burden on the global healthcare sector. This necessitated a swift response from the international community to reach a solution. Efforts were made in parallel to develop preventative and therapeutic modalities. Since then, drug repurposing has blossomed as a potentially rapid resolution and has included various agents with anti-viral and anti-inflammatory properties. Corticosteroids, being potent anti-inflammatory agents, have been placed under extensive investigation. Various trials have recorded the beneficial outcome of corticosteroids in decreasing the mortality and morbidity of COVID-19. With the high pace of escalating events, the quality and study design of clinical trials are varied. Therefore, this study aims to explore the role of corticosteroids in COVID-19 disease. It inspects the molecular, pharmacologic, and clinical proof behind this theory. |
format | Online Article Text |
id | pubmed-10461317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104613172023-08-29 Corticosteroids in COVID-19: pros and cons Bahsoun, Aymen Fakih, Yeva Zareef, Rana Bitar, Fadi Arabi, Mariam Front Med (Lausanne) Medicine The wide and rapid spread of the COVID-19 pandemic has placed an unanticipated burden on the global healthcare sector. This necessitated a swift response from the international community to reach a solution. Efforts were made in parallel to develop preventative and therapeutic modalities. Since then, drug repurposing has blossomed as a potentially rapid resolution and has included various agents with anti-viral and anti-inflammatory properties. Corticosteroids, being potent anti-inflammatory agents, have been placed under extensive investigation. Various trials have recorded the beneficial outcome of corticosteroids in decreasing the mortality and morbidity of COVID-19. With the high pace of escalating events, the quality and study design of clinical trials are varied. Therefore, this study aims to explore the role of corticosteroids in COVID-19 disease. It inspects the molecular, pharmacologic, and clinical proof behind this theory. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461317/ /pubmed/37644981 http://dx.doi.org/10.3389/fmed.2023.1202504 Text en Copyright © 2023 Bahsoun, Fakih, Zareef, Bitar and Arabi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Bahsoun, Aymen Fakih, Yeva Zareef, Rana Bitar, Fadi Arabi, Mariam Corticosteroids in COVID-19: pros and cons |
title | Corticosteroids in COVID-19: pros and cons |
title_full | Corticosteroids in COVID-19: pros and cons |
title_fullStr | Corticosteroids in COVID-19: pros and cons |
title_full_unstemmed | Corticosteroids in COVID-19: pros and cons |
title_short | Corticosteroids in COVID-19: pros and cons |
title_sort | corticosteroids in covid-19: pros and cons |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461317/ https://www.ncbi.nlm.nih.gov/pubmed/37644981 http://dx.doi.org/10.3389/fmed.2023.1202504 |
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