Fibroblasts – the cellular choreographers of wound healing

Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to...

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Autores principales: Knoedler, Samuel, Broichhausen, Sonja, Guo, Ruiji, Dai, Ruoxuan, Knoedler, Leonard, Kauke-Navarro, Martin, Diatta, Fortunay, Pomahac, Bohdan, Machens, Hans-Guenther, Jiang, Dongsheng, Rinkevich, Yuval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461395/
https://www.ncbi.nlm.nih.gov/pubmed/37646029
http://dx.doi.org/10.3389/fimmu.2023.1233800
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author Knoedler, Samuel
Broichhausen, Sonja
Guo, Ruiji
Dai, Ruoxuan
Knoedler, Leonard
Kauke-Navarro, Martin
Diatta, Fortunay
Pomahac, Bohdan
Machens, Hans-Guenther
Jiang, Dongsheng
Rinkevich, Yuval
author_facet Knoedler, Samuel
Broichhausen, Sonja
Guo, Ruiji
Dai, Ruoxuan
Knoedler, Leonard
Kauke-Navarro, Martin
Diatta, Fortunay
Pomahac, Bohdan
Machens, Hans-Guenther
Jiang, Dongsheng
Rinkevich, Yuval
author_sort Knoedler, Samuel
collection PubMed
description Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.
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spelling pubmed-104613952023-08-29 Fibroblasts – the cellular choreographers of wound healing Knoedler, Samuel Broichhausen, Sonja Guo, Ruiji Dai, Ruoxuan Knoedler, Leonard Kauke-Navarro, Martin Diatta, Fortunay Pomahac, Bohdan Machens, Hans-Guenther Jiang, Dongsheng Rinkevich, Yuval Front Immunol Immunology Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461395/ /pubmed/37646029 http://dx.doi.org/10.3389/fimmu.2023.1233800 Text en Copyright © 2023 Knoedler, Broichhausen, Guo, Dai, Knoedler, Kauke-Navarro, Diatta, Pomahac, Machens, Jiang and Rinkevich https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Knoedler, Samuel
Broichhausen, Sonja
Guo, Ruiji
Dai, Ruoxuan
Knoedler, Leonard
Kauke-Navarro, Martin
Diatta, Fortunay
Pomahac, Bohdan
Machens, Hans-Guenther
Jiang, Dongsheng
Rinkevich, Yuval
Fibroblasts – the cellular choreographers of wound healing
title Fibroblasts – the cellular choreographers of wound healing
title_full Fibroblasts – the cellular choreographers of wound healing
title_fullStr Fibroblasts – the cellular choreographers of wound healing
title_full_unstemmed Fibroblasts – the cellular choreographers of wound healing
title_short Fibroblasts – the cellular choreographers of wound healing
title_sort fibroblasts – the cellular choreographers of wound healing
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461395/
https://www.ncbi.nlm.nih.gov/pubmed/37646029
http://dx.doi.org/10.3389/fimmu.2023.1233800
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