Arginine cluster introduction on framework region in anti‐lysozyme antibody improved association rate constant by changing conformational diversity of CDR loops

Antibodies are used for many therapeutic and biotechnological purposes. Because the affinity of an antibody to the antigen is critical for clinical efficacy of pharmaceuticals, many affinity maturation strategies have been developed. Although we previously reported an affinity maturation strategy in...

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Detalles Bibliográficos
Autores principales: Maeta, Shingo, Nakakido, Makoto, Matsuura, Hiroaki, Sakai, Naoki, Hirata, Kunio, Kuroda, Daisuke, Fukunaga, Atsushi, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461459/
https://www.ncbi.nlm.nih.gov/pubmed/37550885
http://dx.doi.org/10.1002/pro.4745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461459/
https://www.ncbi.nlm.nih.gov/pubmed/37550885
http://dx.doi.org/10.1002/pro.4745

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