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NOTCH signalling – a core regulator of bile duct disease?

The Notch signalling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues. Although it was originally identified as a critical regulator of embryonic liv...

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Detalles Bibliográficos
Autores principales: Martinez Lyons, Anabel, Boulter, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461466/
https://www.ncbi.nlm.nih.gov/pubmed/37605966
http://dx.doi.org/10.1242/dmm.050231
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author Martinez Lyons, Anabel
Boulter, Luke
author_facet Martinez Lyons, Anabel
Boulter, Luke
author_sort Martinez Lyons, Anabel
collection PubMed
description The Notch signalling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues. Although it was originally identified as a critical regulator of embryonic liver development, NOTCH signalling activation has been associated with the pathogenesis of a number of paediatric and adult liver diseases. It remains unclear, however, what role NOTCH actually plays in these pathophysiological processes and whether NOTCH activity represents the reactivation of a conserved developmental programme that is essential for adult tissue repair. In this Review, we explore the concepts that NOTCH signalling reactivation in the biliary epithelium is a reiterative and essential response to bile duct damage and that, in disease contexts in which biliary epithelial cells need to be regenerated, NOTCH signalling supports ductular regrowth. Furthermore, we evaluate the recent literature on NOTCH signalling as a critical factor in progenitor-mediated hepatocyte regeneration, which indicates that the mitogenic role for NOTCH signalling in biliary epithelial cell proliferation has also been co-opted to support other forms of epithelial regeneration in the adult liver.
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spelling pubmed-104614662023-08-29 NOTCH signalling – a core regulator of bile duct disease? Martinez Lyons, Anabel Boulter, Luke Dis Model Mech Review The Notch signalling pathway is an evolutionarily conserved mechanism of cell–cell communication that mediates cellular proliferation, fate determination and maintenance of stem/progenitor cell populations across tissues. Although it was originally identified as a critical regulator of embryonic liver development, NOTCH signalling activation has been associated with the pathogenesis of a number of paediatric and adult liver diseases. It remains unclear, however, what role NOTCH actually plays in these pathophysiological processes and whether NOTCH activity represents the reactivation of a conserved developmental programme that is essential for adult tissue repair. In this Review, we explore the concepts that NOTCH signalling reactivation in the biliary epithelium is a reiterative and essential response to bile duct damage and that, in disease contexts in which biliary epithelial cells need to be regenerated, NOTCH signalling supports ductular regrowth. Furthermore, we evaluate the recent literature on NOTCH signalling as a critical factor in progenitor-mediated hepatocyte regeneration, which indicates that the mitogenic role for NOTCH signalling in biliary epithelial cell proliferation has also been co-opted to support other forms of epithelial regeneration in the adult liver. The Company of Biologists Ltd 2023-08-22 /pmc/articles/PMC10461466/ /pubmed/37605966 http://dx.doi.org/10.1242/dmm.050231 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Martinez Lyons, Anabel
Boulter, Luke
NOTCH signalling – a core regulator of bile duct disease?
title NOTCH signalling – a core regulator of bile duct disease?
title_full NOTCH signalling – a core regulator of bile duct disease?
title_fullStr NOTCH signalling – a core regulator of bile duct disease?
title_full_unstemmed NOTCH signalling – a core regulator of bile duct disease?
title_short NOTCH signalling – a core regulator of bile duct disease?
title_sort notch signalling – a core regulator of bile duct disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461466/
https://www.ncbi.nlm.nih.gov/pubmed/37605966
http://dx.doi.org/10.1242/dmm.050231
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