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Phenomics as an approach to Comparative Developmental Physiology

The dynamic nature of developing organisms and how they function presents both opportunity and challenge to researchers, with significant advances in understanding possible by adopting innovative approaches to their empirical study. The information content of the phenotype during organismal developm...

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Autores principales: McCoy, Jamie C. S., Spicer, John I., Ibbini, Ziad, Tills, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461620/
https://www.ncbi.nlm.nih.gov/pubmed/37645563
http://dx.doi.org/10.3389/fphys.2023.1229500
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author McCoy, Jamie C. S.
Spicer, John I.
Ibbini, Ziad
Tills, Oliver
author_facet McCoy, Jamie C. S.
Spicer, John I.
Ibbini, Ziad
Tills, Oliver
author_sort McCoy, Jamie C. S.
collection PubMed
description The dynamic nature of developing organisms and how they function presents both opportunity and challenge to researchers, with significant advances in understanding possible by adopting innovative approaches to their empirical study. The information content of the phenotype during organismal development is arguably greater than at any other life stage, incorporating change at a broad range of temporal, spatial and functional scales and is of broad relevance to a plethora of research questions. Yet, effectively measuring organismal development, and the ontogeny of physiological regulations and functions, and their responses to the environment, remains a significant challenge. “Phenomics”, a global approach to the acquisition of phenotypic data at the scale of the whole organism, is uniquely suited as an approach. In this perspective, we explore the synergies between phenomics and Comparative Developmental Physiology (CDP), a discipline of increasing relevance to understanding sensitivity to drivers of global change. We then identify how organismal development itself provides an excellent model for pushing the boundaries of phenomics, given its inherent complexity, comparably smaller size, relative to adult stages, and the applicability of embryonic development to a broad suite of research questions using a diversity of species. Collection, analysis and interpretation of whole organismal phenotypic data are the largest obstacle to capitalising on phenomics for advancing our understanding of biological systems. We suggest that phenomics within the context of developing organismal form and function could provide an effective scaffold for addressing grand challenges in CDP and phenomics.
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spelling pubmed-104616202023-08-29 Phenomics as an approach to Comparative Developmental Physiology McCoy, Jamie C. S. Spicer, John I. Ibbini, Ziad Tills, Oliver Front Physiol Physiology The dynamic nature of developing organisms and how they function presents both opportunity and challenge to researchers, with significant advances in understanding possible by adopting innovative approaches to their empirical study. The information content of the phenotype during organismal development is arguably greater than at any other life stage, incorporating change at a broad range of temporal, spatial and functional scales and is of broad relevance to a plethora of research questions. Yet, effectively measuring organismal development, and the ontogeny of physiological regulations and functions, and their responses to the environment, remains a significant challenge. “Phenomics”, a global approach to the acquisition of phenotypic data at the scale of the whole organism, is uniquely suited as an approach. In this perspective, we explore the synergies between phenomics and Comparative Developmental Physiology (CDP), a discipline of increasing relevance to understanding sensitivity to drivers of global change. We then identify how organismal development itself provides an excellent model for pushing the boundaries of phenomics, given its inherent complexity, comparably smaller size, relative to adult stages, and the applicability of embryonic development to a broad suite of research questions using a diversity of species. Collection, analysis and interpretation of whole organismal phenotypic data are the largest obstacle to capitalising on phenomics for advancing our understanding of biological systems. We suggest that phenomics within the context of developing organismal form and function could provide an effective scaffold for addressing grand challenges in CDP and phenomics. Frontiers Media S.A. 2023-08-14 /pmc/articles/PMC10461620/ /pubmed/37645563 http://dx.doi.org/10.3389/fphys.2023.1229500 Text en Copyright © 2023 McCoy, Spicer, Ibbini and Tills. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
McCoy, Jamie C. S.
Spicer, John I.
Ibbini, Ziad
Tills, Oliver
Phenomics as an approach to Comparative Developmental Physiology
title Phenomics as an approach to Comparative Developmental Physiology
title_full Phenomics as an approach to Comparative Developmental Physiology
title_fullStr Phenomics as an approach to Comparative Developmental Physiology
title_full_unstemmed Phenomics as an approach to Comparative Developmental Physiology
title_short Phenomics as an approach to Comparative Developmental Physiology
title_sort phenomics as an approach to comparative developmental physiology
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461620/
https://www.ncbi.nlm.nih.gov/pubmed/37645563
http://dx.doi.org/10.3389/fphys.2023.1229500
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AT tillsoliver phenomicsasanapproachtocomparativedevelopmentalphysiology