Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43( A90V ) mutation display a mild reactive state and release polyP toxic to motoneurons

Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). There is compelling evidence that mouse and hu...

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Detalles Bibliográficos
Autores principales: Rojas, Fabiola, Aguilar, Rodrigo, Almeida, Sandra, Fritz, Elsa, Corvalán, Daniela, Ampuero, Estibaliz, Abarzúa, Sebastián, Garcés, Polett, Amaro, Armando, Diaz, Iván, Arredondo, Cristian, Cortes, Nicole, Sanchez, Mario, Mercado, Constanza, Varela-Nallar, Lorena, Gao, Fen-Biao, Montecino, Martin, van Zundert, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461635/
https://www.ncbi.nlm.nih.gov/pubmed/37645251
http://dx.doi.org/10.3389/fcell.2023.1226604

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