Genomic Characteristics of Emerging Intraerythrocytic Anaplasma capra and High Prevalence in Goats, China

Anaplasma capra is an emerging tickborne human pathogen initially recognized in China in 2015; it has been reported in ticks and in a wide range of domestic and wild animals worldwide. We describe whole-genome sequences of 2 A. capra strains from metagenomic sequencing of purified erythrocytes from...

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Detalles Bibliográficos
Autores principales: Lin, Zhe-Tao, Du, Li-Feng, Zhang, Ming-Zhu, Han, Xiao-Yu, Wang, Bai-Hui, Meng, Jiao, Yu, Fu-Xun, Zhou, Xiao-Quan, Wang, Ning, Li, Cheng, Wang, Xiao-Yang, Liu, Jing, Gao, Wan-Ying, Ye, Run-Ze, Xia, Luo-Yuan, Sun, Yi, Jia, Na, Jiang, Jia-Fu, Zhao, Lin, Cui, Xiao-Ming, Zhan, Lin, Cao, Wu-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461651/
https://www.ncbi.nlm.nih.gov/pubmed/37610104
http://dx.doi.org/10.3201/eid2909.230131
Descripción
Sumario:Anaplasma capra is an emerging tickborne human pathogen initially recognized in China in 2015; it has been reported in ticks and in a wide range of domestic and wild animals worldwide. We describe whole-genome sequences of 2 A. capra strains from metagenomic sequencing of purified erythrocytes from infected goats in China. The genome of A. capra was the smallest among members of the genus Anaplasma. The genomes of the 2 A. capra strains contained comparable G+C content and numbers of pseudogenes with intraerythrocytic Anaplasma species. The 2 A. capra strains had 54 unique genes. The prevalence of A. capra was high among goats in the 2 endemic areas. Phylogenetic analyses revealed that the A. capra strains detected in this study were basically classified into 2 subclusters with those previously detected in Asia. Our findings clarify details of the genomic characteristics of A. capra and shed light on its genetic diversity.

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