Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

Interrupting glucagon signaling decreases gluconeogenesis and the fractional extraction of amino acids by liver from blood resulting in lower glycemia. The resulting hyperaminoacidemia stimulates α cell proliferation and glucagon secretion via a liver-α cell axis. We hypothesized that α cells detect...

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Detalles Bibliográficos
Autores principales: Spears, Erick, Stanley, Jade E., Shou, Matthew, Yin, Linlin, Li, Xuan, Dai, Chunhua, Bradley, Amber, Sellick, Katelyn, Poffenberger, Greg, Coate, Katie C., Shrestha, Shristi, Jenkins, Regina, Sloop, Kyle W., Wilson, Keith T., Attie, Alan D., Keller, Mark P., Chen, Wenbiao, Powers, Alvin C., Dean, E. Danielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461917/
https://www.ncbi.nlm.nih.gov/pubmed/37645716
http://dx.doi.org/10.1101/2023.08.10.552656

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