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IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs
Microglia are innate immune cells in the brain. Transcription factor IRF8 is highly expressed in microglia. However, its role in postnatal microglia development and the mechanism of action is unknown. We demonstrate here that IRF8 binds to enhancer regions of postnatal microglia in a stepwise fashio...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461927/ https://www.ncbi.nlm.nih.gov/pubmed/37645844 http://dx.doi.org/10.1101/2023.06.25.546453 |