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Mechanical force regulates ligand binding and function of PD-1

Immune checkpoint blockade targeting PD-1 shows great success in cancer therapy. However, the mechanism of how ligand binding initiates PD-1 signaling remains unclear. As prognosis markers of multiple cancers, soluble PD-L1 is found in patient sera and can bind PD-1, but fails to suppress T cell fun...

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Detalles Bibliográficos
Autores principales:	Li, Kaitao, Cardenas-Lizana, Paul, Kellner, Anna V., Yuan, Zhou, Ahn, Eunseon, Lyu, Jintian, Li, Zhenhai, Salaita, Khalid, Ahmed, Rafi, Zhu, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462004/ https://www.ncbi.nlm.nih.gov/pubmed/37645980 http://dx.doi.org/10.1101/2023.08.13.553152

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