CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion homeostasis in many different mammalian tissues and cell types. Among the nine mammalian CLC homologs, CLC-2 is uniquely activated by hyperpolarization, rather than depolarization, of the plasma membrane. T...

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Detalles Bibliográficos
Autores principales: Xu, Mengyuan, Neelands, Torben, Powers, Alexander S., Liu, Yan, Miller, Steven D., Pintilie, Grigore, Du Bois, J., Dror, Ron O., Chiu, Wah, Maduke, Merritt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462068/
https://www.ncbi.nlm.nih.gov/pubmed/37645939
http://dx.doi.org/10.1101/2023.08.13.553136

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