Massively Parallel Reporter Assay Confirms Regulatory Potential of hQTLs and Reveals Important Variants in Lupus and Other Autoimmune Diseases

OBJECTIVE: To systematically characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs), expression QTLs (eQTLs), and variants on systemic lupus erythematosus (SLE) and autoimmune (AI) disease risk haplotypes to modulate gene expression in...

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Detalles Bibliográficos
Autores principales: Fu, Yao, Kelly, Jennifer A., Gopalakrishnan, Jaanam, Pelikan, Richard C., Tessneer, Kandice L., Pasula, Satish, Grundahl, Kiely, Murphy, David A., Gaffney, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462090/
https://www.ncbi.nlm.nih.gov/pubmed/37645944
http://dx.doi.org/10.1101/2023.08.17.553722

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