ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein duo ESAT-6 and CFP-10. CFP-10 likely acts as a ch...

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Detalles Bibliográficos
Autores principales: Bates, Timothy A, Trank-Greene, Mila, Nguyenla, Xammy, Anastas, Aidan, Merutka, Ilaria R, Dixon, Shandee D, Shumate, Anthony, Groncki, Abigail R, Parson, Matthew AH, Barklis, Eric, Burke, John E, Shinde, Ujwal, Ploegh, Hidde L, Tafesse, Fikadu G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462100/
https://www.ncbi.nlm.nih.gov/pubmed/37645775
http://dx.doi.org/10.1101/2023.08.16.553641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462100/
https://www.ncbi.nlm.nih.gov/pubmed/37645775
http://dx.doi.org/10.1101/2023.08.16.553641

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