Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-phosphorylation. However, it is often unclear which of these PTM...

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Detalles Bibliográficos
Autores principales: Nadel, Cory M., Wucherer, Kristin, Oehler, Abby, Thwin, Aye C., Basu, Koli, Callahan, Matthew D., Southworth, Daniel R., Mordes, Daniel A., Craik, Charles S., Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462110/
https://www.ncbi.nlm.nih.gov/pubmed/37645969
http://dx.doi.org/10.1101/2023.08.16.553575

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