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Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Althoug...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462114/ https://www.ncbi.nlm.nih.gov/pubmed/37645876 http://dx.doi.org/10.1101/2023.08.18.553864 |
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author | Ho, Yi-Yun Yang, Qiuwei Boddu, Priyanka Bulkin, David A. Warden, Melissa R. |
author_facet | Ho, Yi-Yun Yang, Qiuwei Boddu, Priyanka Bulkin, David A. Warden, Melissa R. |
author_sort | Ho, Yi-Yun |
collection | PubMed |
description | The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions. |
format | Online Article Text |
id | pubmed-10462114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-104621142023-08-29 Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance Ho, Yi-Yun Yang, Qiuwei Boddu, Priyanka Bulkin, David A. Warden, Melissa R. bioRxiv Article The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions. Cold Spring Harbor Laboratory 2023-08-18 /pmc/articles/PMC10462114/ /pubmed/37645876 http://dx.doi.org/10.1101/2023.08.18.553864 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Ho, Yi-Yun Yang, Qiuwei Boddu, Priyanka Bulkin, David A. Warden, Melissa R. Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title | Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title_full | Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title_fullStr | Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title_full_unstemmed | Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title_short | Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
title_sort | ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462114/ https://www.ncbi.nlm.nih.gov/pubmed/37645876 http://dx.doi.org/10.1101/2023.08.18.553864 |
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