Cargando…

Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance

The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Althoug...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, Yi-Yun, Yang, Qiuwei, Boddu, Priyanka, Bulkin, David A., Warden, Melissa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462114/
https://www.ncbi.nlm.nih.gov/pubmed/37645876
http://dx.doi.org/10.1101/2023.08.18.553864
_version_ 1785097991811497984
author Ho, Yi-Yun
Yang, Qiuwei
Boddu, Priyanka
Bulkin, David A.
Warden, Melissa R.
author_facet Ho, Yi-Yun
Yang, Qiuwei
Boddu, Priyanka
Bulkin, David A.
Warden, Melissa R.
author_sort Ho, Yi-Yun
collection PubMed
description The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions.
format Online
Article
Text
id pubmed-10462114
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-104621142023-08-29 Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance Ho, Yi-Yun Yang, Qiuwei Boddu, Priyanka Bulkin, David A. Warden, Melissa R. bioRxiv Article The ventromedial prefrontal cortex (vmPFC) is essential for regulating the balance between reactive and adaptive response. Reactive, hard-wired behaviors – such as freezing or flight – are feasible in some situations, but in others contexts an acquired, adaptive action may be more effective. Although the vmPFC has been implicated in adaptive threat avoidance, the contribution of distinct vmPFC neural subtypes with differing molecular identities and wiring patterns is poorly understood. Here, we studied vmPFC parvalbumin (PV) interneurons in mice as they learned to cross a chamber in order to avoid an impending shock, a behavior that requires both learned, adaptive action and the suppression of cued freezing. We found that vmPFC PV neural activity increased upon movement to avoid the shock, when the competing freezing response was suppressed. However, neural activity did not change upon movement toward cued rewards or during general locomotion, conditions with no competing behavior. Optogenetic suppression of vmPFC PV neurons delayed the onset of avoidance behavior and increased the duration of freezing, but did not affect movement toward rewards or general locomotion. Thus, vmPFC PV neurons support flexible, adaptive behavior by suppressing the expression of prepotent behavioral reactions. Cold Spring Harbor Laboratory 2023-08-18 /pmc/articles/PMC10462114/ /pubmed/37645876 http://dx.doi.org/10.1101/2023.08.18.553864 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Ho, Yi-Yun
Yang, Qiuwei
Boddu, Priyanka
Bulkin, David A.
Warden, Melissa R.
Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title_full Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title_fullStr Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title_full_unstemmed Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title_short Ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
title_sort ventromedial prefrontal parvalbumin neurons are necessary for initiating cued threat avoidance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462114/
https://www.ncbi.nlm.nih.gov/pubmed/37645876
http://dx.doi.org/10.1101/2023.08.18.553864
work_keys_str_mv AT hoyiyun ventromedialprefrontalparvalbuminneuronsarenecessaryforinitiatingcuedthreatavoidance
AT yangqiuwei ventromedialprefrontalparvalbuminneuronsarenecessaryforinitiatingcuedthreatavoidance
AT boddupriyanka ventromedialprefrontalparvalbuminneuronsarenecessaryforinitiatingcuedthreatavoidance
AT bulkindavida ventromedialprefrontalparvalbuminneuronsarenecessaryforinitiatingcuedthreatavoidance
AT wardenmelissar ventromedialprefrontalparvalbuminneuronsarenecessaryforinitiatingcuedthreatavoidance