Programmable multi-kilobase RNA editing using CRISPR-mediated trans-splicing

Current gene editing approaches in eukaryotic cells are limited to single base edits or small DNA insertions and deletions, and remain encumbered by unintended permanent effects and significant challenges in the delivery of large DNA cargo. Here we describe Splice Editing, a generalizable platform t...

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Detalles Bibliográficos
Autores principales: Borrajo, Jacob, Javanmardi, Kamyab, Griffin, James, St. Martin, Susan J., Yao, David, Hill, Kaisle, Blainey, Paul C., Al-Shayeb, Basem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462116/
https://www.ncbi.nlm.nih.gov/pubmed/37645763
http://dx.doi.org/10.1101/2023.08.18.553620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462116/
https://www.ncbi.nlm.nih.gov/pubmed/37645763
http://dx.doi.org/10.1101/2023.08.18.553620

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