Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q

Although genome wide association studies (GWAS) have been crucial for the identification of loci associated with sleep traits and disorders, the method itself does not directly uncover the underlying causal variants and corresponding effector genes. The overwhelming majority of such variants reside...

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Detalles Bibliográficos
Autores principales: Sonti, Shilpa, Littleton, Sheridan H., Pahl, Matthew C., Zimmerman, Amber J., Chesi, Alessandra, Palermo, Justin, Lasconi, Chiara, Brown, Elizabeth B., Pippin, James A., Wells, Andrew D., Doldur-Balli, Fusun, Pack, Allan I., Gehrman, Phillip R., Keene, Alex C., Grant, S.F.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462147/
https://www.ncbi.nlm.nih.gov/pubmed/37645863
http://dx.doi.org/10.1101/2023.08.17.553739

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