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The microenvironment dictates glycocalyx construction and immune surveillance
Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with in vitro models that do not match the microenvironmental characteristics of human tissues. Using in vitro models which mimic the physical properties of healthy or cancerous tissues and a physiologica...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462183/ https://www.ncbi.nlm.nih.gov/pubmed/37645943 http://dx.doi.org/10.21203/rs.3.rs-3164966/v1 |
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| author | Tharp, Kevin M. Park, Sangwoo Timblin, Greg A. Richards, Alicia L. Berg, Jordan A. Twells, Nicholas M. Riley, Nicholas M. Peltan, Egan L. Shon, D. Judy Stevenson, Erica Tsui, Kimberly Palomba, Francesco Lefebvre, Austin E. Y. T. Soens, Ross W. Ayad, Nadia M.E. Hoeve-Scott, Johanna ten Healy, Kevin Digman, Michelle Dillin, Andrew Bertozzi, Carolyn R. Swaney, Danielle L. Mahal, Lara K. Cantor, Jason R. Paszek, Matthew J. Weaver, Valerie M. |
| author_facet | Tharp, Kevin M. Park, Sangwoo Timblin, Greg A. Richards, Alicia L. Berg, Jordan A. Twells, Nicholas M. Riley, Nicholas M. Peltan, Egan L. Shon, D. Judy Stevenson, Erica Tsui, Kimberly Palomba, Francesco Lefebvre, Austin E. Y. T. Soens, Ross W. Ayad, Nadia M.E. Hoeve-Scott, Johanna ten Healy, Kevin Digman, Michelle Dillin, Andrew Bertozzi, Carolyn R. Swaney, Danielle L. Mahal, Lara K. Cantor, Jason R. Paszek, Matthew J. Weaver, Valerie M. |
| author_sort | Tharp, Kevin M. |
| collection | PubMed |
| description | Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with in vitro models that do not match the microenvironmental characteristics of human tissues. Using in vitro models which mimic the physical properties of healthy or cancerous tissues and a physiologically relevant culture medium, we demonstrate that the chemical and physical properties of the microenvironment regulate the composition and topology of the glycocalyx. Remarkably, we find that cancer and age-related changes in the physical properties of the microenvironment are sufficient to adjust immune surveillance via the topology of the glycocalyx, a previously unknown phenomenon observable only with a physiologically relevant culture medium. |
| format | Online Article Text |
| id | pubmed-10462183 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Journal Experts |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-104621832023-08-29 The microenvironment dictates glycocalyx construction and immune surveillance Tharp, Kevin M. Park, Sangwoo Timblin, Greg A. Richards, Alicia L. Berg, Jordan A. Twells, Nicholas M. Riley, Nicholas M. Peltan, Egan L. Shon, D. Judy Stevenson, Erica Tsui, Kimberly Palomba, Francesco Lefebvre, Austin E. Y. T. Soens, Ross W. Ayad, Nadia M.E. Hoeve-Scott, Johanna ten Healy, Kevin Digman, Michelle Dillin, Andrew Bertozzi, Carolyn R. Swaney, Danielle L. Mahal, Lara K. Cantor, Jason R. Paszek, Matthew J. Weaver, Valerie M. Res Sq Article Efforts to identify anti-cancer therapeutics and understand tumor-immune interactions are built with in vitro models that do not match the microenvironmental characteristics of human tissues. Using in vitro models which mimic the physical properties of healthy or cancerous tissues and a physiologically relevant culture medium, we demonstrate that the chemical and physical properties of the microenvironment regulate the composition and topology of the glycocalyx. Remarkably, we find that cancer and age-related changes in the physical properties of the microenvironment are sufficient to adjust immune surveillance via the topology of the glycocalyx, a previously unknown phenomenon observable only with a physiologically relevant culture medium. American Journal Experts 2023-08-16 /pmc/articles/PMC10462183/ /pubmed/37645943 http://dx.doi.org/10.21203/rs.3.rs-3164966/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
| spellingShingle | Article Tharp, Kevin M. Park, Sangwoo Timblin, Greg A. Richards, Alicia L. Berg, Jordan A. Twells, Nicholas M. Riley, Nicholas M. Peltan, Egan L. Shon, D. Judy Stevenson, Erica Tsui, Kimberly Palomba, Francesco Lefebvre, Austin E. Y. T. Soens, Ross W. Ayad, Nadia M.E. Hoeve-Scott, Johanna ten Healy, Kevin Digman, Michelle Dillin, Andrew Bertozzi, Carolyn R. Swaney, Danielle L. Mahal, Lara K. Cantor, Jason R. Paszek, Matthew J. Weaver, Valerie M. The microenvironment dictates glycocalyx construction and immune surveillance |
| title | The microenvironment dictates glycocalyx construction and immune surveillance |
| title_full | The microenvironment dictates glycocalyx construction and immune surveillance |
| title_fullStr | The microenvironment dictates glycocalyx construction and immune surveillance |
| title_full_unstemmed | The microenvironment dictates glycocalyx construction and immune surveillance |
| title_short | The microenvironment dictates glycocalyx construction and immune surveillance |
| title_sort | microenvironment dictates glycocalyx construction and immune surveillance |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462183/ https://www.ncbi.nlm.nih.gov/pubmed/37645943 http://dx.doi.org/10.21203/rs.3.rs-3164966/v1 |
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