Lowering hippocampal miR-29a expression slows cognitive decline and reduces beta-amyloid deposition in 5xFAD mice

microRNA-29a (miR-29a) increases with age in humans and mice, and, in the brain, it has a role in neuronal maturation and response to inflammation. We previously associated higher miR-29a levels in human brain with faster antemortem cognitive decline, suggesting that lowering miR-29a levels could am...

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Detalles Bibliográficos
Autores principales: Mei, Zhen, Liu, Jiaqi, Schroeder, Jason P, Weinshenker, David, Duong, Duc M., Seyfried, Nicholas T., Li, Yujing, Jin, Peng, Wingo, Aliza P., Wingo, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462195/
https://www.ncbi.nlm.nih.gov/pubmed/37645711
http://dx.doi.org/10.21203/rs.3.rs-3235257/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462195/
https://www.ncbi.nlm.nih.gov/pubmed/37645711
http://dx.doi.org/10.21203/rs.3.rs-3235257/v1

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