Cargando…

Anti-PD-1 immunotherapy with dose-adjusted ultra-hypofractionated re-irradiation in patients with locoregionally recurrent head and neck cancer

INTRODUCTION: Patients with recurrent inoperable squamous-cell head-neck cancer (HNSCC) after chemo-radiotherapy have an ominous prognosis. Re-irradiation can be applied with some efficacy and high toxicity rates. Anti-PD-1 immunotherapy is effective in 25% of patients. Immunogenic death produced by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koukourakis, Ioannis M., Giakzidis, Axiotis G., Koukourakis, Michael I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462536/ https://www.ncbi.nlm.nih.gov/pubmed/37059932 http://dx.doi.org/10.1007/s12094-023-03172-y

Ejemplares similares

Ultra-Hypofractionated Re-Irradiation with Anti-PD-1 Immunotherapy for Locoregionally Recurrent (after Radical Chemo-Radiotherapy) Non-Small Cell Lung Cancer
por: Filippatos, Konstantinos, et al.
Publicado: (2023)

Cutaneous squamous-cell carcinoma of the head-neck area refractory to chemo-radiotherapy: benefit from anti-PD-1 immunotherapy
por: Koukourakis, Ioannis M., et al.
Publicado: (2021)

Long-Term Results of Postoperative Hypofractionated Accelerated Breast and Lymph Node Radiotherapy (HypoAR) with Hypofractionated Boost
por: Koukourakis, Ioannis M., et al.
Publicado: (2021)

Radio-Immunotherapy: A Case Report of ‘Abscopal Hyper-Progression’?
por: Koukourakis, Ioannis M, et al.
Publicado: (2020)

Prognostic and Predictive Relevance of Tumor-Infiltrating Lymphocytes in Squamous Cell Head–Neck Cancer Patients Treated with Radical Radiotherapy/Chemo-Radiotherapy
por: Koukourakis, Ioannis M., et al.
Publicado: (2022)

Next-Generation Sequencing Analysis of Mutations in Circulating Tumor DNA from the Plasma of Patients with Head–Neck Cancer Undergoing Chemo-Radiotherapy Using a Pan-Cancer Cell-Free Assay
por: Koukourakis, Michael I., et al.
Publicado: (2023)

Predictive value of skin invasion in recurrent head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using a cyberknife
por: Yamazaki, Hideya, et al.
Publicado: (2015)

Concurrent Hypofractionated Radiotherapy and 5-Fluorouracil for Advanced Sarcomas of the Bone
por: Zambatis, Charalambos, et al.
Publicado: (1998)

Effect of intratumoral abscess/necrosis on the outcome for head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using CyberKnife®
por: Yamazaki, Hideya, et al.
Publicado: (2017)

Radiobiological analysis of preliminary results of a phase II study of pelvic hypofractionated and accelerated radiotherapy for high-risk prostate cancer patients
por: Nanos, Christos, et al.
Publicado: (2022)

Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma
por: Vordermark, Dirk, et al.
Publicado: (2005)

Proton re-irradiation of unresectable recurrent head and neck cancers
por: Gordon, Konstantin, et al.
Publicado: (2021)

Re-irradiation for recurrent or second primary head and neck cancer
por: Lee, Hye In, et al.
Publicado: (2021)

Assessment and topographic characterization of locoregional recurrences in head and neck tumours
por: Ferreira, Brigida Costa, et al.
Publicado: (2015)

Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head–neck cancer
por: Koukourakis, M I, et al.
Publicado: (2012)

Re-irradiation for locoregionally recurrent tumors of the thorax: a single-institution, retrospective study
por: Sumita, Kiyomi, et al.
Publicado: (2016)

Clinical outcomes and toxicity predictors of thoracic re-irradiation for locoregionally recurrent lung cancer
por: Yang, Wen-Chi, et al.
Publicado: (2020)

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
por: Wigfield, S M, et al.
Publicado: (2008)

Defining the Role of Immunotherapy in the Curative Treatment of Locoregionally Advanced Head and Neck Cancer: Promises, Challenges, and Opportunities
por: Saddawi-Konefka, Robert, et al.
Publicado: (2021)

Re-Irradiation for Recurrent Head and Neck Cancer: Freedom from Cancer Recurrence Rate
por: Mohamad, Issa, et al.
Publicado: (2023)

Feasibility of carbon‐ion radiotherapy for re‐irradiation of locoregionally recurrent, metastatic, or secondary lung tumors
por: Hayashi, Kazuhiko, et al.
Publicado: (2018)

Efficacy and toxicity of re-irradiation for esophageal cancer patients with locoregional recurrence: a retrospective analysis
por: Zhao, Kaikai, et al.
Publicado: (2020)

Optimising tumour coverage and organ at risk sparing for hypofractionated re-irradiation in glioblastoma
por: Pagett, Christopher J.H., et al.
Publicado: (2022)

Salvage Carbon-Ion Radiation Therapy For Locoregionally Recurrent Head and Neck Malignancies
por: Gao, Jing, et al.
Publicado: (2019)

An Extended Hypofractionated Palliative Radiotherapy Regimen for Head and Neck Carcinomas
por: Laursen, Michael, et al.
Publicado: (2018)

Hypofractionated Radiotherapy for Palliation in Locally Advanced Head and Neck Cancer
por: Spartacus, RK, et al.
Publicado: (2017)

Treatment Outcomes of Re-irradiation in Locoregionally Recurrent Rectal Cancer and Clinical Significance of Proper Patient Selection
por: Chung, Seung Yeun, et al.
Publicado: (2019)

The value of moderate dose escalation for re-irradiation of recurrent or second primary head-and-neck cancer
por: Rühle, Alexander, et al.
Publicado: (2020)

Rare entities in head-and-neck cancer: salvage re-irradiation with carbon ions
por: Held, Thomas, et al.
Publicado: (2019)

Hypofractionated chemoradiation for head and cancer: Data from the PET NECK trial
por: Vreugdenhil, M., et al.
Publicado: (2021)

A retrospective study of head and neck re-irradiation for patients with recurrent or second primary head and neck cancer: the McGill University experience
por: Al-Wassia, Rolina, et al.
Publicado: (2015)

Hypofractionated Re-irradiation after Maximal Surgical Resection for Recurrent Glioblastoma: Therapeutic Adequacy and Its Prognosticators of Survival
por: Lee, Jeongshim, et al.
Publicado: (2018)

Survival benefit of re-irradiation in esophageal Cancer patients with Locoregional recurrence: a propensity score-matched analysis
por: Hong, Liang, et al.
Publicado: (2018)

Expression of CD47 and SIRPα Macrophage Immune-Checkpoint Pathway in Non-Small-Cell Lung Cancer
por: Giatromanolaki, Alexandra, et al.
Publicado: (2022)

Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
por: Wedekind, Hanna, et al.
Publicado: (2021)

A plesiotherapy technique for the post‐operative treatment of skin cancer using Ir192 microSelectron.
por: Abatzoglou, Ioannis, et al.
Publicado: (2008)

Ultra-Hypofractionation for Whole-Breast Irradiation in Early Breast Cancer: Interim Analysis of a Prospective Study
por: Sigaudi, Valeria, et al.
Publicado: (2022)

Persistent Post-radiotherapy Pain and Locoregional Recurrence in Head and Neck Cancer-Is There a Hidden Link?
por: Srivastava, Preety, et al.
Publicado: (2015)

Overlapping volumes in re-irradiation for head and neck cancer – an important factor for patient selection
por: Embring, Anna, et al.
Publicado: (2020)

Reirradiation of head and neck cancer focusing on hypofractionated stereotactic body radiation therapy
por: Yamazaki, Hideya, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_chsbn8u1he3jvt0anbchroj4mi