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Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H

Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity factor (Vif) to target specific human A3s for proteasomal degradation. Vif recruits cellular transcription cofactor CBF-β and Cullin-5 (...

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Detalles Bibliográficos
Autores principales:	Ito, Fumiaki, Alvarez-Cabrera, Ana L., Kim, Kyumin, Zhou, Z. Hong, Chen, Xiaojiang S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462622/ https://www.ncbi.nlm.nih.gov/pubmed/37640699 http://dx.doi.org/10.1038/s41467-023-40955-x

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