Cargando…

α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies

There is increasing interest in studying retinal biomarkers for various neurodegenerative diseases. Specific protein aggregates associated with neurodegenerative diseases are present in the retina and could be visualised in a non-invasive way. This study aims to assess the specificity and sensitivit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hart de Ruyter, Frederique J., Morrema, Tjado H. J., den Haan, Jurre, Gase, Gina, Twisk, Jos W. R., de Boer, Johannes F., Scheltens, Philip, Bouwman, Femke H., Verbraak, Frank D., Rozemuller, Annemieke J. M., Hoozemans, Jeroen J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462645/ https://www.ncbi.nlm.nih.gov/pubmed/37640753 http://dx.doi.org/10.1038/s41531-023-00570-5

Ejemplares similares

Amyloid-beta and phosphorylated tau in post-mortem Alzheimer’s disease retinas
por: den Haan, Jurre, et al.
Publicado: (2018)

Different curcumin forms selectively bind fibrillar amyloid beta in post mortem Alzheimer’s disease brains: Implications for in-vivo diagnostics
por: den Haan, Jurre, et al.
Publicado: (2018)

TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration
por: Dijkstra, Anke A., et al.
Publicado: (2023)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Drug Targeting of α-Synuclein Oligomerization in Synucleinopathies
por: Outeiro, Tiago Fleming, et al.
Publicado: (2008)

Cellular Milieu Imparts Distinct Pathological α-Synuclein Strains in α-Synucleinopathies
por: Peng, Chao, et al.
Publicado: (2018)

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
por: Abdelkarim, Hazem, et al.
Publicado: (2018)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
por: Kawahata, Ichiro, et al.
Publicado: (2022)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
por: Schmitz, Matthias, et al.
Publicado: (2023)

Propagative α-synuclein seeds as serum biomarkers for synucleinopathies
por: Okuzumi, Ayami, et al.
Publicado: (2023)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodies
por: Foulds, P.G., et al.
Publicado: (2012)

No difference in retinal fluorescence after oral curcumin intake in amyloid‐proven AD cases compared to controls
por: den Haan, Jurre, et al.
Publicado: (2022)

Low CSF Levels of Both α-Synuclein and the α-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy
por: Wennström, Malin, et al.
Publicado: (2013)

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
por: Rosenberger, Andrea F. N., et al.
Publicado: (2016)

Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
por: Codolo, Gaia, et al.
Publicado: (2013)

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
por: Jakova, Elisabet, et al.
Publicado: (2022)

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
por: Fujita, Masayo, et al.
Publicado: (2012)

Retinal thickness correlates with parietal cortical atrophy in early-onset Alzheimer's disease and controls
por: den Haan, Jurre, et al.
Publicado: (2017)

Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis
por: den Haan, Jurre, et al.
Publicado: (2017)

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
por: Badiola, Nahuai, et al.
Publicado: (2011)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?
por: Hoppe, Simon Oliver, et al.
Publicado: (2021)

Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?
por: Tripathi, Arati, et al.
Publicado: (2021)

Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies
por: Yamasaki, Tritia R., et al.
Publicado: (2020)

Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils
por: Roux, Amandine, et al.
Publicado: (2020)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
por: Mizuno, Hideya, et al.
Publicado: (2010)

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
por: Sekigawa, Akio, et al.
Publicado: (2015)

Skin α-synuclein deposits differ in clinical variants of synucleinopathy: an in vivo study
por: Donadio, V., et al.
Publicado: (2018)

In Search of Effective Treatments Targeting α-Synuclein Toxicity in Synucleinopathies: Pros and Cons
por: Fouka, Maria, et al.
Publicado: (2020)

A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies
por: Hartlage-Rübsamen, Maike, et al.
Publicado: (2021)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
por: Luk, Kelvin C., et al.
Publicado: (2012)

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies
por: Kisos, Haya, et al.
Publicado: (2012)

Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy
por: Wang, Xue-Jing, et al.
Publicado: (2020)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
por: Gu, Hao, et al.
Publicado: (2021)

Development of α-Synuclein Real-Time Quaking-Induced Conversion as a Diagnostic Method for α-Synucleinopathies
por: Nakagaki, Takehiro, et al.
Publicado: (2021)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy
por: Spencer, Brian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_iasmp7e43sjdrg130rcr3acsek