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Engaging an HIV vaccine target through the acquisition of low B cell affinity

Low affinity is common for germline B cell receptors (BCR) seeding development of broadly neutralizing antibodies (bnAbs) that engage hypervariable viruses, including HIV. Antibody affinity selection is also non-homogenizing, insuring the survival of low affinity B cell clones. To explore whether th...

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Detalles Bibliográficos
Autores principales:	Ronsard, Larance, Yousif, Ashraf S., Nait Mohamed, Faez Amokrane, Feldman, Jared, Okonkwo, Vintus, McCarthy, Caitlin, Schnabel, Julia, Caradonna, Timothy, Barnes, Ralston M., Rohrer, Daniel, Lonberg, Nils, Schmidt, Aaron, Lingwood, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462694/ https://www.ncbi.nlm.nih.gov/pubmed/37640732 http://dx.doi.org/10.1038/s41467-023-40918-2

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