Cargando…

CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

Osteoarthritis is a prevalent age-related disease characterized by dysregulation of extracellular matrix metabolism, lipid metabolism, and upregulation of senescence-associated secretory phenotypes. Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes and its de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Zhe, Zhu, Jinjin, Chen, Junxin, Feng, Fan, Zhang, Haitao, Zhang, Zheyuan, Song, Chenxin, Liang, Kaiyu, Yang, Shuhui, Fan, Shunwu, Fang, Xiangqian, Shen, Shuying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462713/ https://www.ncbi.nlm.nih.gov/pubmed/37640697 http://dx.doi.org/10.1038/s41467-023-40975-7

Ejemplares similares

CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post‐translational modification
por: Gong, Zhe, et al.
Publicado: (2023)

Stem cell–homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model
por: Zhu, Jinjin, et al.
Publicado: (2022)

CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes
por: Liang, Yi, et al.
Publicado: (2023)

A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis
por: Gong, Zhe, et al.
Publicado: (2023)

FASN activity is important for the initial stages of the induction of senescence
por: Fafián-Labora, Juan, et al.
Publicado: (2019)

CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc
por: Shen, Shuying, et al.
Publicado: (2020)

CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
por: Chen, Junxin, et al.
Publicado: (2019)

Correction to: CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
por: Chen, Junxin, et al.
Publicado: (2020)

The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis
por: Zhang, Chenzhi, et al.
Publicado: (2020)

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene
por: Shen, Shuying, et al.
Publicado: (2019)

Transcription Factor RREB1: from Target Genes towards Biological Functions
por: Deng, Ya-Nan, et al.
Publicado: (2020)

circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1
por: Shen, Shuying, et al.
Publicado: (2021)

Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
por: Yang, Yute, et al.
Publicado: (2021)

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration
por: Wang, Jianle, et al.
Publicado: (2022)

Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression
por: Wu, Yizheng, et al.
Publicado: (2019)

CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells
por: Liu, Gang, et al.
Publicado: (2018)

CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
por: Chen, Zizheng, et al.
Publicado: (2023)

CircSLC7A2 protects against osteoarthritis through inhibition of the miR‐4498/TIMP3 axis
por: Ni, Weiyu, et al.
Publicado: (2021)

The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-β pathway
por: Li, Hao, et al.
Publicado: (2023)

Author Correction: CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
por: Chen, Zizheng, et al.
Publicado: (2023)

Identification of Acetylation Sites of Fatty Acid Synthase (FASN) by Mass Spectrometry and FASN Activity Assay
por: Miao, Ting, et al.
Publicado: (2023)

Modified poly(methyl methacrylate) bone cement in the treatment of Kümmell disease
por: Zhu, Jinjin, et al.
Publicado: (2021)

Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18
por: Wu, Yizheng, et al.
Publicado: (2021)

Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut of Drosophila
por: Baechler, Brittany L., et al.
Publicado: (2015)

Regulatory SNP of RREB1 is Associated With Bone Mineral Density in Chinese Postmenopausal Osteoporosis Patients
por: Feng, Shuo, et al.
Publicado: (2021)

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos
por: Morgani, Sophie M, et al.
Publicado: (2021)

Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis
por: Inubushi, Toshihiro, et al.
Publicado: (2022)

SREBP1/FASN/cholesterol axis facilitates radioresistance in colorectal cancer
por: Jin, Yuxiao, et al.
Publicado: (2021)

Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis
por: Yao, Teng, et al.
Publicado: (2021)

Effect of autophagy induced by dexamethasone on senescence in chondrocytes
por: Xue, Enxing, et al.
Publicado: (2016)

MBRS-12. A TRANSPOSON MUTAGENESIS SCREEN IDENTIFIES Rreb1 AS A DRIVER FOR GROUP 3 MEDULLOBLASTOMA
por: Masihi, Meher Beigi, et al.
Publicado: (2020)

The fasn-1(g14ts) allele is a Gly1830Arg missense mutation in C. elegans FASN-1
por: Bai, Xiaofei, et al.
Publicado: (2020)

CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2
por: Shen, Panyang, et al.
Publicado: (2020)

Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes
por: Kent, Oliver A., et al.
Publicado: (2020)

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
por: Mattis, Katia K., et al.
Publicado: (2023)

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer
por: Yang, Li, et al.
Publicado: (2016)

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice
por: Shao, Yan, et al.
Publicado: (2021)

miR-10a-5p Promotes Chondrocyte Apoptosis in Osteoarthritis by Targeting HOXA1
por: Ma, Yan, et al.
Publicado: (2018)

Delayed postoperative spinal epidural hematoma after anterior cervical discectomy and fusion: A case report
por: Xu, Wenbin, et al.
Publicado: (2022)

A Novel Tongue-Based Tumor With an RREB1-MRTFB Fusion: Variant Rhabdomyosarcoma or Aggressive Variant of Ectomesenchymal Chondromyxoid Tumor
por: Sumransub, Nuttavut, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cfmbp639f8s86j3v25hmgi36m1