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Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization

Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists exami...

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Autores principales: Zuniga-Chaves, Ibrahim, Eggers, Shoshannah, Kates, Ashley E., Safdar, Nasia, Suen, Garret, Malecki, Kristen M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462741/
https://www.ncbi.nlm.nih.gov/pubmed/37640705
http://dx.doi.org/10.1038/s41522-023-00430-3
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author Zuniga-Chaves, Ibrahim
Eggers, Shoshannah
Kates, Ashley E.
Safdar, Nasia
Suen, Garret
Malecki, Kristen M. C.
author_facet Zuniga-Chaves, Ibrahim
Eggers, Shoshannah
Kates, Ashley E.
Safdar, Nasia
Suen, Garret
Malecki, Kristen M. C.
author_sort Zuniga-Chaves, Ibrahim
collection PubMed
description Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap.
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spelling pubmed-104627412023-08-30 Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization Zuniga-Chaves, Ibrahim Eggers, Shoshannah Kates, Ashley E. Safdar, Nasia Suen, Garret Malecki, Kristen M. C. NPJ Biofilms Microbiomes Article Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap. Nature Publishing Group UK 2023-08-28 /pmc/articles/PMC10462741/ /pubmed/37640705 http://dx.doi.org/10.1038/s41522-023-00430-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zuniga-Chaves, Ibrahim
Eggers, Shoshannah
Kates, Ashley E.
Safdar, Nasia
Suen, Garret
Malecki, Kristen M. C.
Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title_full Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title_fullStr Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title_full_unstemmed Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title_short Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
title_sort neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462741/
https://www.ncbi.nlm.nih.gov/pubmed/37640705
http://dx.doi.org/10.1038/s41522-023-00430-3
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