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Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists exami...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462741/ https://www.ncbi.nlm.nih.gov/pubmed/37640705 http://dx.doi.org/10.1038/s41522-023-00430-3 |
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author | Zuniga-Chaves, Ibrahim Eggers, Shoshannah Kates, Ashley E. Safdar, Nasia Suen, Garret Malecki, Kristen M. C. |
author_facet | Zuniga-Chaves, Ibrahim Eggers, Shoshannah Kates, Ashley E. Safdar, Nasia Suen, Garret Malecki, Kristen M. C. |
author_sort | Zuniga-Chaves, Ibrahim |
collection | PubMed |
description | Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap. |
format | Online Article Text |
id | pubmed-10462741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104627412023-08-30 Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization Zuniga-Chaves, Ibrahim Eggers, Shoshannah Kates, Ashley E. Safdar, Nasia Suen, Garret Malecki, Kristen M. C. NPJ Biofilms Microbiomes Article Social disparities continue to limit universal access to health care, directly impacting both lifespan and quality of life. Concomitantly, the gut microbiome has been associated with downstream health outcomes including the global rise in antibiotic resistance. However, limited evidence exists examining socioeconomic status (SES) associations with gut microbiome composition. To address this, we collected information on the community-level SES, gut microbiota, and other individual cofactors including colonization by multidrug-resistant organisms (MDROs) in an adult cohort from Wisconsin, USA. We found an association between SES and microbial composition that is mediated by food insecurity. Additionally, we observed a higher prevalence of MDROs isolated from individuals with low diversity microbiomes and low neighborhood SES. Our integrated population-based study considers how the interplay of several social and economic factors combine to influence gut microbial composition while providing a framework for developing future interventions to help mitigate the SES health gap. Nature Publishing Group UK 2023-08-28 /pmc/articles/PMC10462741/ /pubmed/37640705 http://dx.doi.org/10.1038/s41522-023-00430-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zuniga-Chaves, Ibrahim Eggers, Shoshannah Kates, Ashley E. Safdar, Nasia Suen, Garret Malecki, Kristen M. C. Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title | Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title_full | Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title_fullStr | Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title_full_unstemmed | Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title_short | Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
title_sort | neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462741/ https://www.ncbi.nlm.nih.gov/pubmed/37640705 http://dx.doi.org/10.1038/s41522-023-00430-3 |
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