Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quantitative interpretation remains uncertain. We show that TSPO...

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Detalles Bibliográficos
Autores principales: Nutma, Erik, Fancy, Nurun, Weinert, Maria, Tsartsalis, Stergios, Marzin, Manuel C., Muirhead, Robert C. J., Falk, Irene, Breur, Marjolein, de Bruin, Joy, Hollaus, David, Pieterman, Robin, Anink, Jasper, Story, David, Chandran, Siddharthan, Tang, Jiabin, Trolese, Maria C., Saito, Takashi, Saido, Takaomi C., Wiltshire, Katharine H., Beltran-Lobo, Paula, Phillips, Alexandra, Antel, Jack, Healy, Luke, Dorion, Marie-France, Galloway, Dylan A., Benoit, Rochelle Y., Amossé, Quentin, Ceyzériat, Kelly, Badina, Aurélien M., Kövari, Enikö, Bendotti, Caterina, Aronica, Eleonora, Radulescu, Carola I., Wong, Jia Hui, Barron, Anna M., Smith, Amy M., Barnes, Samuel J., Hampton, David W., van der Valk, Paul, Jacobson, Steven, Howell, Owain W., Baker, David, Kipp, Markus, Kaddatz, Hannes, Tournier, Benjamin B., Millet, Philippe, Matthews, Paul M., Moore, Craig S., Amor, Sandra, Owen, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462763/
https://www.ncbi.nlm.nih.gov/pubmed/37640701
http://dx.doi.org/10.1038/s41467-023-40937-z

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