Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists

Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed chimeric mRNAs encoding single-chain IL-12 fused to...

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Detalles Bibliográficos
Autores principales: Cirella, Assunta, Bolaños, Elixabet, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Olivera, Irene, Gomis, Gabriel, Glez-Vaz, Javier, Pinci, Beatrice, Garasa, Saray, Sánchez-Gregorio, Sandra, Azpilikueta, Arantza, Eguren-Santamaria, Iñaki, Valencia, Karmele, Palencia, Belén, Alvarez, Maite, Ochoa, Maria C., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462790/
https://www.ncbi.nlm.nih.gov/pubmed/37650116
http://dx.doi.org/10.1016/j.omtn.2023.07.026

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