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Endothelin Receptor-A Inhibition Decreases Ductular Reaction, Liver Fibrosis, and Angiogenesis in a Model of Cholangitis

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) leads to ductular reaction and fibrosis and is complicated by vascular dysfunction. Cholangiocyte and endothelial cell crosstalk modulates their proliferation in cholestatic models. Endothelin (ET)-1 and ET-2 bind to their receptor, ET-A, a...

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Detalles Bibliográficos
Autores principales:	Owen, Travis, Carpino, Guido, Chen, Lixian, Kundu, Debjyoti, Wills, Payton, Ekser, Burcin, Onori, Paolo, Gaudio, Eugenio, Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462792/ https://www.ncbi.nlm.nih.gov/pubmed/37336290 http://dx.doi.org/10.1016/j.jcmgh.2023.06.005

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