Nucleolar Essential Protein 1 (Nep1): Elucidation of enzymatic catalysis mechanism by molecular dynamics simulation and quantum mechanics study

The Nep1 protein is essential for the formation of eukaryotic and archaeal small ribosomal subunits, and it catalyzes the site-directed SAM-dependent methylation of pseudouridine (Ψ) during pre-rRNA processing. It possesses a non–trivial topology, namely, a 3(1) knot in the active site. Here, we add...

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Detalles Bibliográficos
Autores principales: Jedrzejewski, Mateusz, Belza, Barbara, Lewandowska, Iwona, Sadlej, Marta, Perlinska, Agata P., Augustyniak, Rafal, Christian, Thomas, Hou, Ya-Ming, Kalek, Marcin, Sulkowska, Joanna I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462857/
https://www.ncbi.nlm.nih.gov/pubmed/37649713
http://dx.doi.org/10.1016/j.csbj.2023.08.001

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