Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications

Microscopic colitis is a chronic inflammatory condition of the colon characterized by chronic watery diarrhea, generally with endoscopically normal or nonspecific findings, and can be diagnosed by histopathological examination of colon mucosal biopsies. Some patients experience severe symptoms that...

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Autores principales: Rim, Daniel Sungku, Shin, Jeong-Hun, Jacoba, Isa, Sharma, Kavita, Kim, Dong Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462905/
https://www.ncbi.nlm.nih.gov/pubmed/37649980
http://dx.doi.org/10.3389/fmed.2023.1231565
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author Rim, Daniel Sungku
Shin, Jeong-Hun
Jacoba, Isa
Sharma, Kavita
Kim, Dong Wook
author_facet Rim, Daniel Sungku
Shin, Jeong-Hun
Jacoba, Isa
Sharma, Kavita
Kim, Dong Wook
author_sort Rim, Daniel Sungku
collection PubMed
description Microscopic colitis is a chronic inflammatory condition of the colon characterized by chronic watery diarrhea, generally with endoscopically normal or nonspecific findings, and can be diagnosed by histopathological examination of colon mucosal biopsies. Some patients experience severe symptoms that do not respond to conventional medical treatment. A glucagon-like peptide-2 (GLP-2) analog, teduglutide, is used in patients with short bowel syndrome (SBS) dependent on parenteral support. In this case report, we describe a patient with microscopic colitis who demonstrated significant symptom improvement following teduglutide treatment.
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spelling pubmed-104629052023-08-30 Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications Rim, Daniel Sungku Shin, Jeong-Hun Jacoba, Isa Sharma, Kavita Kim, Dong Wook Front Med (Lausanne) Medicine Microscopic colitis is a chronic inflammatory condition of the colon characterized by chronic watery diarrhea, generally with endoscopically normal or nonspecific findings, and can be diagnosed by histopathological examination of colon mucosal biopsies. Some patients experience severe symptoms that do not respond to conventional medical treatment. A glucagon-like peptide-2 (GLP-2) analog, teduglutide, is used in patients with short bowel syndrome (SBS) dependent on parenteral support. In this case report, we describe a patient with microscopic colitis who demonstrated significant symptom improvement following teduglutide treatment. Frontiers Media S.A. 2023-08-15 /pmc/articles/PMC10462905/ /pubmed/37649980 http://dx.doi.org/10.3389/fmed.2023.1231565 Text en Copyright © 2023 Rim, Shin, Jacoba, Sharma and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Rim, Daniel Sungku
Shin, Jeong-Hun
Jacoba, Isa
Sharma, Kavita
Kim, Dong Wook
Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title_full Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title_fullStr Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title_full_unstemmed Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title_short Case report: Exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
title_sort case report: exploring teduglutide as a therapeutic option for refractory microscopic colitis: insights and implications
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462905/
https://www.ncbi.nlm.nih.gov/pubmed/37649980
http://dx.doi.org/10.3389/fmed.2023.1231565
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