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Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462942/ https://www.ncbi.nlm.nih.gov/pubmed/37640409 http://dx.doi.org/10.1136/bcr-2023-255909 |
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author | Sun, George Weiss, Allison Zhao, Joy Silver, Mitchell DeMaio, Michael Dehbashi, Sara |
author_facet | Sun, George Weiss, Allison Zhao, Joy Silver, Mitchell DeMaio, Michael Dehbashi, Sara |
author_sort | Sun, George |
collection | PubMed |
description | Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly presenting as disseminated invasive fungal infection with cerebrorhino-orbital involvement in an immunocompromised patient. Infections are most commonly caused by direct implantation of spores with localised angioinvasion. Haematogenous spread is rare, with most cases secondary to haematological malignancies or intravenous drug use. Coinfection with mucormycosis and aspergillosis portends a poor prognosis, with a high mortality rate. Thus, prompt recognition and intervention are crucial to prevent poor outcomes. In this unique case report, we describe a case of isolated cerebral mucormycosis and aspergillosis coinfection, not previously reported in literature. |
format | Online Article Text |
id | pubmed-10462942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-104629422023-08-30 Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult Sun, George Weiss, Allison Zhao, Joy Silver, Mitchell DeMaio, Michael Dehbashi, Sara BMJ Case Rep Case Reports: Rare disease Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly presenting as disseminated invasive fungal infection with cerebrorhino-orbital involvement in an immunocompromised patient. Infections are most commonly caused by direct implantation of spores with localised angioinvasion. Haematogenous spread is rare, with most cases secondary to haematological malignancies or intravenous drug use. Coinfection with mucormycosis and aspergillosis portends a poor prognosis, with a high mortality rate. Thus, prompt recognition and intervention are crucial to prevent poor outcomes. In this unique case report, we describe a case of isolated cerebral mucormycosis and aspergillosis coinfection, not previously reported in literature. BMJ Publishing Group 2023-08-27 /pmc/articles/PMC10462942/ /pubmed/37640409 http://dx.doi.org/10.1136/bcr-2023-255909 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Case Reports: Rare disease Sun, George Weiss, Allison Zhao, Joy Silver, Mitchell DeMaio, Michael Dehbashi, Sara Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title | Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title_full | Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title_fullStr | Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title_full_unstemmed | Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title_short | Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult |
title_sort | isolated cerebral mucormycosis and aspergillosis coinfection in an immunocompromised adult |
topic | Case Reports: Rare disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462942/ https://www.ncbi.nlm.nih.gov/pubmed/37640409 http://dx.doi.org/10.1136/bcr-2023-255909 |
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