Cargando…

Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult

Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, George, Weiss, Allison, Zhao, Joy, Silver, Mitchell, DeMaio, Michael, Dehbashi, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462942/
https://www.ncbi.nlm.nih.gov/pubmed/37640409
http://dx.doi.org/10.1136/bcr-2023-255909
_version_ 1785098144217825280
author Sun, George
Weiss, Allison
Zhao, Joy
Silver, Mitchell
DeMaio, Michael
Dehbashi, Sara
author_facet Sun, George
Weiss, Allison
Zhao, Joy
Silver, Mitchell
DeMaio, Michael
Dehbashi, Sara
author_sort Sun, George
collection PubMed
description Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly presenting as disseminated invasive fungal infection with cerebrorhino-orbital involvement in an immunocompromised patient. Infections are most commonly caused by direct implantation of spores with localised angioinvasion. Haematogenous spread is rare, with most cases secondary to haematological malignancies or intravenous drug use. Coinfection with mucormycosis and aspergillosis portends a poor prognosis, with a high mortality rate. Thus, prompt recognition and intervention are crucial to prevent poor outcomes. In this unique case report, we describe a case of isolated cerebral mucormycosis and aspergillosis coinfection, not previously reported in literature.
format Online
Article
Text
id pubmed-10462942
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-104629422023-08-30 Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult Sun, George Weiss, Allison Zhao, Joy Silver, Mitchell DeMaio, Michael Dehbashi, Sara BMJ Case Rep Case Reports: Rare disease Opportunistic fungal infections are a major cause of mortality in immunosuppressed patients, with mucormycosis and aspergillosis as two of the most commonly identified fungal organisms. Coinfection with mucormycosis and aspergillosis is rare, but cases have been reported in literature, most commonly presenting as disseminated invasive fungal infection with cerebrorhino-orbital involvement in an immunocompromised patient. Infections are most commonly caused by direct implantation of spores with localised angioinvasion. Haematogenous spread is rare, with most cases secondary to haematological malignancies or intravenous drug use. Coinfection with mucormycosis and aspergillosis portends a poor prognosis, with a high mortality rate. Thus, prompt recognition and intervention are crucial to prevent poor outcomes. In this unique case report, we describe a case of isolated cerebral mucormycosis and aspergillosis coinfection, not previously reported in literature. BMJ Publishing Group 2023-08-27 /pmc/articles/PMC10462942/ /pubmed/37640409 http://dx.doi.org/10.1136/bcr-2023-255909 Text en © BMJ Publishing Group Limited 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Reports: Rare disease
Sun, George
Weiss, Allison
Zhao, Joy
Silver, Mitchell
DeMaio, Michael
Dehbashi, Sara
Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title_full Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title_fullStr Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title_full_unstemmed Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title_short Isolated cerebral Mucormycosis and Aspergillosis coinfection in an immunocompromised adult
title_sort isolated cerebral mucormycosis and aspergillosis coinfection in an immunocompromised adult
topic Case Reports: Rare disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462942/
https://www.ncbi.nlm.nih.gov/pubmed/37640409
http://dx.doi.org/10.1136/bcr-2023-255909
work_keys_str_mv AT sungeorge isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult
AT weissallison isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult
AT zhaojoy isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult
AT silvermitchell isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult
AT demaiomichael isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult
AT dehbashisara isolatedcerebralmucormycosisandaspergillosiscoinfectioninanimmunocompromisedadult