Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

BACKGROUND: Localized radiotherapy (RT) can cause a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade. However, this effect is still clinically rare and improvements are highly desirable. We investigated whether triple combinat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Liqun, Luo, Ren, Onyshchenko, Kateryna, Rao, Xi, Wang, Meidan, Menz, Beatrice, Gaedicke, Simone, Grosu, Anca-Ligia, Firat, Elke, Niedermann, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462948/
https://www.ncbi.nlm.nih.gov/pubmed/37640480
http://dx.doi.org/10.1136/jitc-2022-006235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462948/
https://www.ncbi.nlm.nih.gov/pubmed/37640480
http://dx.doi.org/10.1136/jitc-2022-006235

Ejemplares similares