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Adding liposomal doxorubicin enhances the abscopal effect induced by radiation/αPD1 therapy depending on tumor cell mitochondrial DNA and cGAS/STING

BACKGROUND: Localized radiotherapy (RT) can cause a T cell-mediated abscopal effect on non-irradiated tumor lesions, especially in combination with immune checkpoint blockade. However, this effect is still clinically rare and improvements are highly desirable. We investigated whether triple combinat...

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Detalles Bibliográficos
Autores principales:	Wang, Liqun, Luo, Ren, Onyshchenko, Kateryna, Rao, Xi, Wang, Meidan, Menz, Beatrice, Gaedicke, Simone, Grosu, Anca-Ligia, Firat, Elke, Niedermann, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462948/ https://www.ncbi.nlm.nih.gov/pubmed/37640480 http://dx.doi.org/10.1136/jitc-2022-006235

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