A practical approach for PD-L1 evaluation in gastroesophageal cancer

PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker,...

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Autores principales: Angerilli, Valentina, Fassan, Matteo, Parente, Paola, Gullo, Irene, Campora, Michela, Rossi, Chiara, Sacramento, Maria Luisa, Pennelli, Gianmaria, Vanoli, Alessandro, Grillo, Federica, Mastracci, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pacini Editore srl 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462995/
https://www.ncbi.nlm.nih.gov/pubmed/36537078
http://dx.doi.org/10.32074/1591-951X-836
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author Angerilli, Valentina
Fassan, Matteo
Parente, Paola
Gullo, Irene
Campora, Michela
Rossi, Chiara
Sacramento, Maria Luisa
Pennelli, Gianmaria
Vanoli, Alessandro
Grillo, Federica
Mastracci, Luca
author_facet Angerilli, Valentina
Fassan, Matteo
Parente, Paola
Gullo, Irene
Campora, Michela
Rossi, Chiara
Sacramento, Maria Luisa
Pennelli, Gianmaria
Vanoli, Alessandro
Grillo, Federica
Mastracci, Luca
author_sort Angerilli, Valentina
collection PubMed
description PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability. This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC).
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spelling pubmed-104629952023-08-30 A practical approach for PD-L1 evaluation in gastroesophageal cancer Angerilli, Valentina Fassan, Matteo Parente, Paola Gullo, Irene Campora, Michela Rossi, Chiara Sacramento, Maria Luisa Pennelli, Gianmaria Vanoli, Alessandro Grillo, Federica Mastracci, Luca Pathologica Review PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability. This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC). Pacini Editore srl 2022-12-19 /pmc/articles/PMC10462995/ /pubmed/36537078 http://dx.doi.org/10.32074/1591-951X-836 Text en © 2023 Copyright by Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access journal distributed in accordance with the CC-BY-NC-ND (Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International) license: the work can be used by mentioning the author and the license, but only for non-commercial purposes and only in the original version. For further information: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en
spellingShingle Review
Angerilli, Valentina
Fassan, Matteo
Parente, Paola
Gullo, Irene
Campora, Michela
Rossi, Chiara
Sacramento, Maria Luisa
Pennelli, Gianmaria
Vanoli, Alessandro
Grillo, Federica
Mastracci, Luca
A practical approach for PD-L1 evaluation in gastroesophageal cancer
title A practical approach for PD-L1 evaluation in gastroesophageal cancer
title_full A practical approach for PD-L1 evaluation in gastroesophageal cancer
title_fullStr A practical approach for PD-L1 evaluation in gastroesophageal cancer
title_full_unstemmed A practical approach for PD-L1 evaluation in gastroesophageal cancer
title_short A practical approach for PD-L1 evaluation in gastroesophageal cancer
title_sort practical approach for pd-l1 evaluation in gastroesophageal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10462995/
https://www.ncbi.nlm.nih.gov/pubmed/36537078
http://dx.doi.org/10.32074/1591-951X-836
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