Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development

The Vps10p domain receptor SorCS2 is crucial for the development and function of the nervous system and essential for brain-derived neurotrophic factor (BDNF)-induced changes in neuronal morphology and plasticity. SorCS2 regulates the subcellular trafficking of the BDNF signaling receptor TrkB as we...

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Detalles Bibliográficos
Autores principales: Skeldal, Sune, Voss, Lasse Frank, Lende, Jonas, Pedersen, Sarah Broholt, Mølgaard, Simon, Kaas, Mathias, Demange, Perline, Bentsen, Andreas Høiberg, Fuglsang, Marie, Sander, Marie Rubin, Buttenschøn, Henriette, Gustafsen, Camilla, Madsen, Peder, Glerup, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463258/
https://www.ncbi.nlm.nih.gov/pubmed/37507021
http://dx.doi.org/10.1016/j.jbc.2023.105102

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