Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production

Oxidative stress triggered by aging, radiation, or inflammation impairs ovarian function by inducing granulosa cell (GC) apoptosis. However, the mechanism inducing GC apoptosis has not been characterized. Here, we found that ovarian GCs from aging patients showed increased oxidative stress, enhanced...

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Detalles Bibliográficos
Autores principales: Zhang, Chun-Xue, Lin, Yu-Ling, Lu, Fei-Fei, Yu, Li-Na, Liu, Yang, Zhou, Ji-Dong, Kong, Na, Li, Dong, Yan, Gui-Jun, Sun, Hai-Xiang, Cao, Guang-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463260/
https://www.ncbi.nlm.nih.gov/pubmed/37543362
http://dx.doi.org/10.1016/j.jbc.2023.105126

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