Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s disease

Evidence that Huntington's disease (HD) is characterized by impaired cholesterol biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly progressing R6/2 mouse model, with a positive therapeutic outcome. Here we tested the long-term efficacy of chronic...

Descripción completa

Detalles Bibliográficos
Autores principales: Birolini, Giulia, Valenza, Marta, Ottonelli, Ilaria, Talpo, Francesca, Minoli, Lucia, Cappelleri, Andrea, Bombaci, Mauro, Caccia, Claudio, Canevari, Caterina, Trucco, Arianna, Leoni, Valerio, Passoni, Alice, Favagrossa, Monica, Nucera, Maria Rosaria, Colombo, Laura, Paltrinieri, Saverio, Bagnati, Renzo, Duskey, Jason Thomas, Caraffi, Riccardo, Vandelli, Maria Angela, Taroni, Franco, Salmona, Mario, Scanziani, Eugenio, Biella, Gerardo, Ruozi, Barbara, Tosi, Giovanni, Cattaneo, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463277/
https://www.ncbi.nlm.nih.gov/pubmed/37336430
http://dx.doi.org/10.1016/j.phrs.2023.106823

Ejemplares similares

Ejemplares similares