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Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

BACKGROUND: The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos with variable efficiency. Transcytosis involves...

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Detalles Bibliográficos
Autores principales:	Esparza, Thomas J., Su, Shiran, Francescutti, Caroline M., Rodionova, Elvira, Kim, Joong Hee, Brody, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463325/ https://www.ncbi.nlm.nih.gov/pubmed/37620930 http://dx.doi.org/10.1186/s12987-023-00462-z

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