Comprehensive analysis on subchondral bone marrow lesions of human osteoarthritis by integrating bulk and single-cell transcriptomes

OBJECTIVE: This study aims to demonstrate the cellular composition and underlying mechanisms in subchondral bone marrow lesions (BMLs) of knee osteoarthritis (OA). METHODS: BMLs were assessed by MRI Osteoarthritis Knee Score (MOAKS)≥2. Bulk RNA-sequencing (bulk-seq) and BML-specific differentially e...

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Detalles Bibliográficos
Autores principales: Zeng, Muhui, Wang, Xiaoshuai, Chen, Tianyu, Ruan, Guangfeng, Li, Jia, Xue, Song, Zhao, Yang, Hu, Zhiyang, Xie, Ye, Fan, Tianxiang, Chen, Shibo, Li, Yang, Wang, Qianyi, Zhang, Yue, Zhang, Rongkai, Lin, Lijun, Ding, Changhai, Zhu, Zhaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10463447/
https://www.ncbi.nlm.nih.gov/pubmed/37626330
http://dx.doi.org/10.1186/s12891-023-06676-4

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